Elucidating the biology of yeast in its full complexity has major implications for science,
medicine and industry. One of the most critical processes determining yeast life and …

Yeasts, such as Saccharomyces cerevisiae, have long served as useful models for the study
of oxidative stress, an event associated with cell death and severe human pathologies. This …

In the search for interventions against aging and age-related diseases, biological screening
platforms are indispensable tools to identify anti-aging compounds among large substance …

Understanding lipid-induced malfunction represents a major challenge of today's biomedical
research. The connection of lipids to cellular and organ dysfunction, cell death, and disease …

The concept of ageing is one that has intrigued mankind since the beginning of time and is
now more important than ever as the incidence of age-related disorders is increasing in our …

The Saccharomyces cerevisiae protein kinase Sch9 is an in vitro and in vivo effector of
sphingolipid signaling. This study examines the link between Sch9 and sphingolipid …

How do cells age and die? For the past 20 years, the budding yeast, Saccharomyces
cerevisiae, has been used as a model organism to uncover the genes that regulate lifespan …

The notion that cellular membranes contain distinct microdomains, acting as scaffolds for
signal transduction processes, has gained considerable momentum. In particular, a class of …

Lactoferrin (Lf) is a bioactive milk-derived protein with remarkable wide-spectrum antifungal
activity. To deepen our understanding of the molecular mechanisms underlying Lf …

The dynamic nature of the actin cytoskeleton is required to coordinate many cellular
processes, and a loss of its plasticity has been linked to accelerated cell aging and …