Acetylcholine in the brain alters neuronal excitability, influences synaptic transmission,
induces synaptic plasticity, and coordinates firing of groups of neurons. As a result, it …

Among the many neuromodulators used by the mammalian brain to regulate circuit function
and plasticity, dopamine (DA) stands out as one of the most behaviorally powerful …

The striatal and pallidal complexes are basal ganglia structures that orchestrate learning
and execution of flexible behavior. Models of how the basal ganglia subserve these …

This Perspective will examine the organization of intrastriatal circuitry, review recent findings
in this area, and discuss how the pattern of connectivity between striatal neurons might give …

In this review we propose that there are sex differences in how men and women enter onto
the path that can lead to addiction. Males are more likely than females to engage in risky …

The dorsal striatum, the largest subcortical structure of the basal ganglia, is critical in
controlling motor, procedural, and reinforcement-based behaviors. Although in mammals the …

Striatal cholinergic interneurons (ChIs) are central for the processing and reinforcement of
reward‐related behaviors that are negatively affected in states of altered dopamine …

The basal ganglia network serves to integrate information about context, actions, and
outcomes to shape the behavior of an animal based on its past experience. Clinically, the …

The purpose of this review is to bridge the gap between earlier literature on striatal
cholinergic interneurons and mechanisms of microcircuit interaction demonstrated with the …

Interplay between dopaminergic and cholinergic neuromodulation in the striatum is crucial
for movement control, with prominent models proposing pro-kinetic and anti-kinetic effects of …