The importance of the cell wall to the viability of the bacterium is underscored by the breadth
of antibiotic structures that act by blocking key enzymes that are tasked with cell-wall …

Many Gram‐negative and Gram‐positive bacteria recycle a significant proportion of the
peptidoglycan components of their cell walls during their growth and septation. In many …

β-Lactam antibiotics are one of the most important antibiotic classes but are plagued by
problems of resistance, and the development of new β-lactam antibiotics through side-chain …

Small RNAs (sRNAs) constitute a large and heterogeneous class of bacterial gene
expression regulators. Much like eukaryotic microRNAs, these sRNAs typically target …

Resistance mechanisms of Pseudomonas aeruginosa to ceftolozane/tazobactam (C/T) were
assessed on a collection of 420 nonredundant strains nonsusceptible to ceftazidime (MIC> 8 …

This review deeply addresses for the first time the diversity, regulation and mechanisms
leading to mutational overexpression of intrinsic β-lactamases from non-fermenting and …

In Enterobacteriaceae, the transcriptional regulator AmpR, a member of the LysR family,
regulates the expression of a chromosomal β-lactamase AmpC. The regulatory repertoire of …

Previously, by targeting penicillin-binding protein 3, Pseudomonas-derived
cephalosporinase (PDC), and MurA with ceftazidime-avibactam-fosfomycin, antimicrobial …

The hyperproduction of the chromosomal AmpC β-lactamase is the main mechanism driving
β-lactam resistance in Pseudomonas aeruginosa, one of the leading opportunistic …

Enterobacter cloacae complex (ECC), an opportunistic pathogen causing numerous
infections in hospitalized patients worldwide, is able to resist β-lactams mainly by producing …