This article updates the Heart Failure Association of the European Society of Cardiology
(ESC) 2007 classification of advanced heart failure and describes new diagnostic and …

Cardiovascular diseases are the leading cause of death worldwide. Endothelial dysfunction,
inflammation and oxidative stress are at the forefront in the onset and development of …

Abstract Machine learning and artificial intelligence are generating significant attention in
the scientific community and media. Such algorithms have great potential in medicine for …

Despite improvements in pharmacological therapy and pacing, prognosis in advanced heart
failure (HF) remains poor, with a 1‐year mortality of 25–50%. While heart transplantation …

We propose that stage D advanced heart failure be defined as the presence of progressive
and/or persistent severe signs and symptoms of heart failure despite optimized medical …

Left ventricular assist devices are becoming an increasingly prevalent therapy for patients
with Stage D heart failure with reduced ejection fraction. Technological advances have …

Abstract Background: The HeartMate 3 left ventricular assist system (LVAS) is intended to
provide long-term support to patients with advanced heart failure. The centrifugal flow pump …

Background Right ventricular failure (RVF) is a major cause of morbidity and mortality after
left ventricular assist device (LVAD) implantation. The pulmonary artery pulsatility index …

Background Clinical trials inform on average efficacy, but individualized risk assessments for
outcome prediction are important in guiding treatment implementation. Objectives The …

Mechanical circulatory support (MCS) evolved from an engineering dream to clinical reality
during the 1980s when increasing numbers of patients were dying on heart transplant wait …