The most superficial layer of the spinal dorsal horn, lamina I, is a key element of the
nociceptive processing system. It contains different types of projection neurons (PNs) and …

Cold water immersion (CWI) evokes the life-threatening reflex cold shock response (CSR),
inducing hyperventilation, increasing cardiac arrhythmias, and increasing drowning risk by …

The superficial dorsal horn (SDH) of the spinal cord represents the first site of integration
between innocuous and noxious somatosensory stimuli. According to gate control theory …

Spinal projection neurons (PNs) are defined by long axons that travel from their origin in the
spinal cord to the brain where they relay sensory information from the body. The existence …

Projection neurons in the spinal dorsal horn relay sensory information to higher brain
centres. The activation of these populations is shaped by afferent input from the periphery …

The periaqueductal gray (PAG) represents a key target of projection neurons residing in the
spinal dorsal horn. In comparison to lamina I spinoparabrachial neurons, little is known …

High-threshold dorsal root ganglion (HT DRG) neurons fire at low frequencies during
inflammatory injury, and low-frequency stimulation (LFS) of HT DRG neurons selectively …

Cervical and trigeminal afferents innervate neighboring cranial territories, and their
convergence on upper cervical dorsal horn neurons provides a potential substrate for pain …

While exteroceptive sensory processing is a hallmark of autism spectrum disorder, how
interoceptive processing may impact and contribute to symptomatology remains unclear. In …

Alteration of synaptic function in the dorsal horn (DH) has been implicated as a cellular
substrate for the development of neuropathic pain, but certain details remain unclear. In …