Prediction of deleterious human alleles
Single nucleotide polymorphisms (SNPs) constitute the bulk of human genetic variation,
occurring with an average density of∼ 1/1000 nucleotides of a genotype. SNPs are either …
occurring with an average density of∼ 1/1000 nucleotides of a genotype. SNPs are either …
BLEEP—potential of mean force describing protein–ligand interactions: I. Generating potential
JBO Mitchell, RA Laskowski, A Alex… - Journal of …, 1999 - Wiley Online Library
We have developed Bleep (biomolecular ligand energy evaluation protocol), an atomic level
potential of mean force (PMF) describing protein–ligand interactions. The pair potentials for …
potential of mean force (PMF) describing protein–ligand interactions. The pair potentials for …
Charged residues next to transmembrane regions revisited:“Positive-inside rule” is complemented by the “negative inside depletion/outside enrichment rule”
Abstract Background Transmembrane helices (TMHs) frequently occur amongst protein
architectures as means for proteins to attach to or embed into biological membranes …
architectures as means for proteins to attach to or embed into biological membranes …
Effects of hands-free cellular phone conversational cognitive tasks on driving stability based on driving simulation experiment
Driver distraction due to cellular phone usage is a major contributing factor to road crashes.
This study compares the effects of conversational cognitive tasks using hands-free cellular …
This study compares the effects of conversational cognitive tasks using hands-free cellular …
Effects of amino acid composition, finite size of proteins, and sparse statistics on distance‐dependent statistical pair potentials
D Rykunov, A Fiser - Proteins: Structure, Function, and …, 2007 - Wiley Online Library
Statistical distance dependent pair potentials are frequently used in a variety of folding,
threading, and modeling studies of proteins. The applicability of these types of potentials is …
threading, and modeling studies of proteins. The applicability of these types of potentials is …
Information‐theoretic dissection of pairwise contact potentials
Pairwise contact potentials have a long, successful history in protein structure prediction.
They provide an easily‐estimated representation of many attributes of protein structures …
They provide an easily‐estimated representation of many attributes of protein structures …
Protein threading by recursive dynamic programming
We present the recursive dynamic programming (RDP) method for the threading approach
to three-dimensional protein structure prediction. RDP is based on the divide-and-conquer …
to three-dimensional protein structure prediction. RDP is based on the divide-and-conquer …
Prediction of sequence signals for lipid post‐translational modifications: insights from case studies
In silico annotation techniques for post‐translational modifications (PTMs) are important to
generate biologically meaningful descriptions for sequences of experimentally …
generate biologically meaningful descriptions for sequences of experimentally …
Identifying protein-kinase-specific phosphorylation sites based on the bagging–adaboost ensemble approach
Protein phosphorylation is an important step in many biological processes, such as cell
cycles, membrane transport, apoptosis, etc. In order to obtain more useful information about …
cycles, membrane transport, apoptosis, etc. In order to obtain more useful information about …
Phosphatidylcholine Activation of Human Heart (R)-3-Hydroxybutyrate Dehydrogenase Mutants Lacking Active Center Sulfhydryls: Site-Directed Mutagenesis of a …
D Chelius, C Loeb-Hennard, S Fleischer… - Biochemistry, 2000 - ACS Publications
(R)-3-Hydroxybutyrate dehydrogenase (BDH) is a lipid-requiring mitochondrial enzyme with
a specific requirement of phosphatidylcholine (PC) for function. A plasmid has been …
a specific requirement of phosphatidylcholine (PC) for function. A plasmid has been …