The molecular basis and enzyme engineering strategies for improvement of coupling efficiency in cytochrome P450s
Cytochrome P450s are heme-thiolate enzymes that have been broadly applied in
pharmaceutical and biosynthesis because of their efficient oxidation at inert carbons …
pharmaceutical and biosynthesis because of their efficient oxidation at inert carbons …
Harnessing heme chemistry: Recent advances in the biocatalytic applications of cytochrome P450 monooxgenases
Abstract Cytochrome P450 monooxygenases (CYPs/P450s) are heme-thiolate proteins with
broad chemical functionality that have widespread application as powerful biocatalysts …
broad chemical functionality that have widespread application as powerful biocatalysts …
Engineering P450 Monooxygenases for Highly Regioselective and Active p-Hydroxylation of m-Alkylphenols
RJ Li, K Tian, X Li, AR Gaikaiwari, Z Li - ACS Catalysis, 2022 - ACS Publications
Regioselective hydroxylations of aromatic compounds are useful reactions but often lack
appropriate catalysts. Here a group of P450BM3 mutants (R47I/A82F/A328F …
appropriate catalysts. Here a group of P450BM3 mutants (R47I/A82F/A328F …
Introduction of aromatic amino acids in electron transfer pathways yielded improved catalytic performance of cytochrome P450s
Cytochrome P450s are versatile catalysts for biosynthesis applications. In the P450 catalytic
cycle, two electrons are required to reduce the heme iron and activate the subsequent …
cycle, two electrons are required to reduce the heme iron and activate the subsequent …
Prokaryotic expression and characterization of artificial self-sufficient CYP120A monooxygenases
RY Ye, J Song, ZJ Zhang, HL Yu - Applied Microbiology and Biotechnology, 2023 - Springer
Abstract Cytochrome P450 monooxygenases CYP120As are the unique non-membrane
P450s, which are extensively involved in retinoid biodegradation. As the O-functionalized 1 …
P450s, which are extensively involved in retinoid biodegradation. As the O-functionalized 1 …
Empowering cytochrome P450 catalysis by understanding coupling efficiency
Kurzfassung Cytochrom P450-Monooxygenasen (P450s), eine Superfamilie von Häm-
Thiolat-Enzymen, haben entscheidende katalytische Fähigkeiten in der pharmazeutischen …
Thiolat-Enzymen, haben entscheidende katalytische Fähigkeiten in der pharmazeutischen …