As the “chemical chameleon”, sulfonyl-containing compounds and their variants have been
merged with various types of reactions for the efficient construction of diverse molecular …

The quest to find milder and more sustainable methods to generate highly reactive, carbon-
centred intermediates has led to a resurgence of interest in radical chemistry. In particular …

Mechanistic investigations of the Ni-catalyzed asymmetric reductive alkenylation of N-
hydroxyphthalimide (NHP) esters and benzylic chlorides are reported. Investigations of the …

The past decade has witnessed the emergence of N-(acyloxy) phthalimides (NHPI esters)
and its derivatives at the forefront of synthetic methods facilitating the construction of diverse …

We report herein a modular class of organic catalysts that, acting as donors, can readily form
photoactive electron donor–acceptor (EDA) complexes with a variety of radical precursors …

Despite decades of ground-breaking research in academia, organic synthesis is still a rate-
limiting factor in drug-discovery projects. Here we present some current challenges in …

The conversion of widely available carboxylic acids into versatile boronic esters would be
highly enabling for synthesis. We found that this transformation can be effected by …

Advances in bioconjugation and native protein modification are appearing at a blistering
pace, making it increasingly time consuming for practitioners to identify the best chemical …

Recent years have witnessed a resurgence of novel, efficient and practical protocols for
radical‐mediated cross‐coupling reactions involving N‐(acyloxy) phthalimides (NHPI esters) …

Catalytic cross-coupling reactions of aromatic esters and amides have recently gained
considerable attention from synthetic chemists as de novo and efficient synthetic methods to …