RNA interference (RNAi) provides researchers with a versatile means to modulate target
gene expression. The major forms of RNAi molecules, genome-derived microRNAs …

Small interfering RNAs (siRNAs), which downregulate gene expression guided by sequence
complementarity, can be used therapeutically to block the synthesis of disease-causing …

A key end goal of gene delivery research is to develop clinically relevant vectors that can be
used to combat elusive diseases such as AIDS. Despite promising engineering strategies …

Small-molecule and protein/antibody drugs mainly act on genome-derived proteins to exert
pharmacological effects. RNA based therapies hold the promise to expand the range of …

Plant pathogenic fungi are the largest group of disease-causing agents on crop plants and
represent a persistent and significant threat to agriculture worldwide. Conventional …

Transcription and translation are fundamental cellular processes that govern the protein
production of cells. These processes are generally up regulated in cancer cells, to maintain …

RNA interference (RNAi) is the biological process of mRNA degradation induced by
complementary sequences double-stranded (ds) small interfering RNAs (siRNA) and …

Current crop pest control strategies rely on insecticidal and fungicidal sprays, plant genetic
resistance, transgenes and agricultural practices. However, many insects, plant viruses, and …

Small interfering RNA (siRNA) is a promising drug candidate, expected to have broad
therapeutic potentials toward various diseases including viral infections and cancer. With …

Oligonucleotides (ONs) are gaining increasing importance as a promising novel class of
biopharmaceuticals. Thanks to their fundamental role in gene regulation, they can be used …