Methods for the identification and characterization of extracellular vesicles in cardiovascular studies: from exosomes to microvesicles

SM Davidson, CM Boulanger, E Aikawa… - Cardiovascular …, 2023 - academic.oup.com
Extracellular vesicles (EVs) are nanosized vesicles with a lipid bilayer that are released from
cells of the cardiovascular system, and are considered important mediators of intercellular …

Extracellular vesicles in cardiovascular diseases: From pathophysiology to diagnosis and therapy

Y Du, L Wu, L Wang, RJ Reiter, GYH Lip… - Cytokine & Growth Factor …, 2023 - Elsevier
Extracellular vesicles (EVs), encompassing exosomes, microvesicles (MVs), and apoptotic
bodies (ABs), are cell-derived heterogeneous nanoparticles with a pivotal role in …

Therapeutic potential of EVs: Targeting cardiovascular diseases

J Laura Francés, C Pagiatakis, V Di Mauro, M Climent - Biomedicines, 2023 - mdpi.com
Due to their different biological functions, extracellular vesicles (EVs) have great potential
from a therapeutic point of view. They are released by all cell types, carrying and delivering …

Intercellular mitochondrial component transfer triggers ischemic cardiac fibrosis

C Zhang, H Hao, Y Wang, N Mu, W Jiang, Z Zhang… - Science Bulletin, 2023 - Elsevier
Myocardial fibrosis is the villain of sudden cardiac death. Myocardial ischemia/reperfusion
(MI/R) injury induces cardiomyocyte damage or even death, which in turn stimulates …

Intravenously transplanted mesenchymal stromal cells: a new endocrine reservoir for cardioprotection

A Huang, Y Liu, X Qi, S Chen, H Huang… - Stem cell research & …, 2022 - Springer
Background Intravenous administration of mesenchymal stromal cells (MSCs) has an
acknowledged competence of cardiac repair, despite a lack of systematic description of the …

Insight into extracellular vesicles in vascular diseases: intercellular communication role and clinical application potential

W Liu, M Jin, Q Chen, Q Li, X Xing, Y Luo… - Cell Communication and …, 2023 - Springer
Background Cells have been increasingly known to release extracellular vesicles (EVs) to
the extracellular environment under physiological and pathological conditions. A plethora of …

Yin-Yang: two sides of extracellular vesicles in inflammatory diseases

B Zeng, Y Li, N Khan, A Su, Y Yang, P Mi… - Journal of …, 2024 - Springer
Abstract The concept of Yin-Yang, originating in ancient Chinese philosophy, symbolizes
two opposing but complementary forces or principles found in all aspects of life. This …

Systemic delivery of divalent europium from ligand screening with implications to direct imaging of hypoxia

MM Rashid, BA Corbin, P Jella, CJ Ortiz… - Journal of the …, 2022 - ACS Publications
Hypoxia is a hallmark of many diseases, including cancer, arthritis, heart and kidney
diseases, and diabetes, and it is often associated with disease aggressiveness and poor …

The emerging role of epigenetics in therapeutic targeting of cardiomyopathies

C Pagiatakis, V Di Mauro - International Journal of Molecular Sciences, 2021 - mdpi.com
Cardiomyopathies (CMPs) are a heterogeneous group of myocardial diseases accountable
for the majority of cases of heart failure (HF) and/or sudden cardiac death (SCD) worldwide …

Non-coding RNAs in cell-to-cell communication: exploiting physiological mechanisms as therapeutic targets in cardiovascular pathologies

J Laura Francés, E Musolino, R Papait… - International Journal of …, 2023 - mdpi.com
Cardiovascular disease, the leading cause of death worldwide, has been characterized at
the molecular level by alterations in gene expression that contribute to the etiology of the …