Radiotherapy (RT) is one of the mainstay treatments for prostate cancer (PCa), a highly
prevalent neoplasm among males worldwide. About 30% of newly diagnosed PCa patients …

Radiotherapy is a major cancer treatment option but dose-limiting side effects such as late-
onset fibrosis in the irradiated tissue severely impair quality of life in cancer survivors. Efforts …

DNA damage response (DDR) in eukaryotic cells is initiated in the chromatin context. DNA
damage and repair depend on or have influence on the chromatin dynamics associated with …

Plants orchestrate various DNA damage responses (DDRs) to overcome the deleterious
impacts of genotoxic agents on genetic materials. Ionizing radiation (IR) is widely used as a …

Radiotherapy is an important component of anti-cancer treatment. However, not all cancer
patients respond to radiotherapy, and with current knowledge clinicians are unable to …

Epigenetic mechanisms play a key role in non-targeted effects of radiation. The purpose of
this study was to investigate global hypomethylation and promoter hypermethylation of …

Radiotherapy is a well-established regimen for nearly half the cancer patients worldwide.
However, not all cancer patients respond to irradiation treatment, and radioresistance is …

Ionizing radiation (IR) therapy is a major cancer treatment modality and an indispensable
auxiliary treatment for primary and metastatic cancers, but invariably results in debilitating …

Global DNA hypomethylation is proposed as a potential biomarker for cancer risk associated
with genomic instability, which is an important factor in radiation‐induced cancer. However …

Purpose: With widespread use of ionizing radiation, more attention has been attracted to low-
dose radiation (LDR); however, the mechanisms of long-term LDR-induced bio-effects are …