During nervous system development, neurons extend axons to reach their targets and form
functional circuits. The faulty assembly or disintegration of such circuits results in disorders …

Background Cuproptosis is a newly discovered unique non-apoptotic programmed cell
death distinguished from known death mechanisms like ferroptosis, pyroptosis, and …

Transected axons fail to regrow in the mature central nervous system. Astrocytic scars are
widely regarded as causal in this failure. Here, using three genetically targeted loss-of …

Proper patterning of the nervous system requires that developing axons find appropriate
postsynaptic partners; this entails microns to meters of extension through an extracellular …

The spinal cord receives, relays and processes sensory information from the periphery and
integrates this information with descending inputs from supraspinal centres to elicit precise …

Phosphatase and tensin homolog (PTEN) is a classical tumor suppressor that antagonizes
phosphatidylinositol 3-phosphate kinase (PI3K)/AKT signaling. Although there is a strong …

The development of a functional nervous system entails establishing connectivity between
appropriate synaptic partners. During axonal pathfinding, the developing axon navigates …

Netrin-1 regulates cell migration and adhesion during the development of the nervous
system, vasculature, lung, pancreas, muscle, and mammary gland. It is also proposed to …

Abstract DCC (Deleted in Colorectal Cancer) is a single-pass transmembrane protein that
belongs to the immunoglobulin superfamily. It was originally identified as a prognostic tumor …

Dynamic trafficking of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid glutamate
receptors (AMPARs) to synapses is critical for activity-dependent synaptic plasticity …