Colorectal cancer commonly metastasizes. The liver is the most frequent site of metastases
and dominates the length of survival for this disease. As surgical and systemic therapies …

Brain metastasis (BrM) is a devastating complication of solid tumors associated with poor
outcomes. Immune-checkpoint inhibitors (ICI) have revolutionized the treatment of cancer …

Both the timing and molecular determinants of metastasis are unknown, hindering treatment
and prevention efforts. Here we characterize the evolutionary dynamics of this lethal process …

The clinical success of nanomedicines demands on the development of simple
biodegradable nanocarriers that can efficiently and stably encapsulate chemotherapeutics …

Brain metastases (BM) of colorectal cancer (CRC) are rare but lethal, and an understanding
of their genomic landscape is lacking. We conduct an analysis of whole-exome sequencing …

Brain metastases are more common than primary CNS tumors and confer grave prognosis
on patients, as existing treatments have very limited efficacy. The tumor microenvironment …

Opinion statement Compared to liver and lung metastases, brain metastases (BMs) from
colorectal cancer (CRC) are rare and remain poorly investigated despite the anticipated rise …

Background Real-world data on demographics related to KRAS mutation subtypes are
crucial as targeted drugs against the p. G12C variant have been approved. Method We …

In the current era of molecularly targeted therapies and precision medicine, choice of cancer
treatment has been increasingly tailored according to the molecular or genomic …

Background The association of primary tumor location with incidence and prognosis of brain
or bone metastasis in metastatic colorectal cancer (mCRC) patients remains unclear. We …