The growth factor brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-
related kinase receptor type B (TRKB) are actively produced and trafficked in multiple …

Brain-derived neurotrophic factor (BDNF) is a small dimeric protein, structurally related to
nerve growth factor, which is abundantly and widely expressed in the adult mammalian …

A major hurdle for functional recovery after both spinal cord injury and cortical stroke is the
limited regrowth of the axons in the corticospinal tract (CST) that originate in the motor cortex …

This review focuses on the potential for traumatic brain injury to evoke both focal and diffuse
changes within the brain parenchyma, while considering the cellular constituents involved …

Stroke remains the leading cause of long-term disability with limited options available to aid
in recovery. Significant effort has been made to try and minimize neuronal damage following …

Traumatic brain injury (TBI) evokes widespread/diffuse axonal injury (TAI) significantly
contributing to its morbidity and mortality. While classic theories suggest that traumatically …

Experimental spinal cord injury (SCI) causes chronic neuropathic pain associated with
inflammatory changes in thalamic pain regulatory sites. Our recent studies examining …

The regenerative capacity of injured adult mammalian central nervous system (CNS) tissue
is very limited. Disease or injury that causes destruction or damage to neuronal networks …

We have generated and characterized a multi-functional polyclonal anti-brain-derived
neurotrophic factor antibody. Western blot analysis, dorsal root ganglion neurite outgrowth …

Background: Recent pathologic investigations have shown that neocortical lesions are
frequent in multiple sclerosis (MS). Structural MRI has shown that neocortical atrophy occurs …