Polymeric delivery of therapeutic nucleic acids

R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

A review of different types of liposomes and their advancements as a form of gene therapy treatment for breast cancer

GYW Tseu, KA Kamaruzaman - Molecules, 2023 - mdpi.com
Breast cancer incidence and mortality rates have increased exponentially during the last
decade, particularly among female patients. Current therapies, including surgery and …

Recent advances in liposome formulations for breast cancer therapeutics

B Yang, B Song, S Shankar, A Guller… - Cellular and Molecular Life …, 2021 - Springer
Among many nanoparticle-based delivery platforms, liposomes have been particularly
successful with many formulations passed into clinical applications. They are well …

[HTML][HTML] mRNA delivery systems for cancer immunotherapy: lipid nanoparticles and beyond

ME Senti, LG Del Valle, RM Schiffelers - Advanced Drug Delivery Reviews, 2024 - Elsevier
Abstract mRNA-based vaccines are emerging as a promising alternative to standard cancer
treatments and the conventional vaccines. Moreover, the FDA-approval of three nucleic acid …

Gene therapy: A promising approach for breast cancer treatment

NT Dastjerd, A Valibeik… - Cell biochemistry …, 2022 - Wiley Online Library
Breast cancer (BC) is the most prevalent malignancy and the second leading cause of death
among women worldwide that is caused by numerous genetic and environmental factors …

Strategies for improving the safety and RNAi efficacy of noncovalent peptide/siRNA nanocomplexes

J Wang, G Chen, N Liu, X Han, F Zhao, L Zhang… - Advances in Colloid and …, 2022 - Elsevier
In the past decades, the striking development of cationic polypeptides and cell-penetrating
peptides (CPPs) tailored for small interfering RNA (siRNA) delivery has been fuelled by the …

Delivery of various cargos into cancer cells and tissues via cell-penetrating peptides: a review of the last decade

A Shoari, R Tooyserkani, M Tahmasebi, DWPM Löwik - Pharmaceutics, 2021 - mdpi.com
Abstracts Cell-penetrating peptides (CPPs), also known as protein transduction domains,
are a class of diverse amino acid sequences with the ability to cross cellular membranes …

[HTML][HTML] Peptide-based delivery of therapeutics in cancer treatment

T Samec, J Boulos, S Gilmore, A Hazelton… - Materials Today Bio, 2022 - Elsevier
Current delivery strategies for cancer therapeutics commonly cause significant systemic side
effects due to required high doses of therapeutic, inefficient cellular uptake of drug, and poor …

A comprehensive review on different approaches for tumor targeting using nanocarriers and recent developments with special focus on multifunctional approaches

BP Sahu, R Baishya, JL Hatiboruah, D Laloo… - Journal of …, 2022 - Springer
Background Despite tremendous advancements in cancer treatment delivery, we are still far
from achieving successful cancer prognosis and cure. The use of new nanocarriers for site …

Ionic liquids: momentous tools in transdermal delivery of biomacromolecules

L Li, Z Tai, X Wu, J Wu, T Zhang, Z Chen… - Advanced …, 2023 - Wiley Online Library
Transdermal drug delivery is a promising strategy characterized by minor fluctuations in
blood concentrations, few adverse effects, convenience, and excellent patient compliance …