Past, present, and future perspectives of transcription factor EB (TFEB): mechanisms of regulation and association with disease
Transcription factor EB (TFEB), a member of the MiT/TFE family of basic helix-loop-helix
leucine zipper transcription factors, is an established central regulator of the …
leucine zipper transcription factors, is an established central regulator of the …
[HTML][HTML] Impairment of the autophagy–lysosomal pathway in Alzheimer's diseases: pathogenic mechanisms and therapeutic potential
Abstract Alzheimer's disease (AD), the most common neurodegenerative disorder, is
characterized by memory loss and cognitive dysfunction. The accumulation of misfolded …
characterized by memory loss and cognitive dysfunction. The accumulation of misfolded …
Amelioration of Alzheimer's disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow
A reduced removal of dysfunctional mitochondria is common to aging and age-related
neurodegenerative pathologies such as Alzheimer's disease (AD). Strategies for treating …
neurodegenerative pathologies such as Alzheimer's disease (AD). Strategies for treating …
Novel target for treating Alzheimer's Diseases: Crosstalk between the Nrf2 pathway and autophagy
W Zhang, C Feng, H Jiang - Ageing research reviews, 2021 - Elsevier
Abstract In mammals, the Keap1-Nrf2-ARE pathway (henceforth,“the Nrf2 pathway”) and
autophagy are major intracellular defence systems that combat oxidative damage and …
autophagy are major intracellular defence systems that combat oxidative damage and …
Autophagy in neurodegenerative diseases: a hunter for aggregates
H Park, JH Kang, S Lee - International Journal of Molecular Sciences, 2020 - mdpi.com
Cells have developed elaborate quality-control mechanisms for proteins and organelles to
maintain cellular homeostasis. Such quality-control mechanisms are maintained by …
maintain cellular homeostasis. Such quality-control mechanisms are maintained by …
Electroacupuncture ameliorates beta-amyloid pathology and cognitive impairment in Alzheimer disease via a novel mechanism involving activation of TFEB …
X Zheng, W Lin, Y Jiang, K Lu, W Wei, Q Huo, S Cui… - Autophagy, 2021 - Taylor & Francis
Alzheimer disease (AD) is the most prevalent neurodegenerative disorder leading to
dementia in the elderly. Unfortunately, no cure for AD is available to date. Increasing …
dementia in the elderly. Unfortunately, no cure for AD is available to date. Increasing …
[HTML][HTML] Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology: Implications for Alzheimer's disease therapy
Abstract Alzheimer's disease (AD), characterized by the accumulation of protein aggregates
including phosphorylated Tau aggregates, is the most common neurodegenerative disorder …
including phosphorylated Tau aggregates, is the most common neurodegenerative disorder …
Tau oligomers neurotoxicity
G Niewiadomska, W Niewiadomski, M Steczkowska… - Life, 2021 - mdpi.com
Although the mechanisms of toxic activity of tau are not fully recognized, it is supposed that
the tau toxicity is related rather not to insoluble tau aggregates but to its intermediate forms. It …
the tau toxicity is related rather not to insoluble tau aggregates but to its intermediate forms. It …
Contribution of astrocytes to neuropathology of neurodegenerative diseases
Classically, the loss of vulnerable neuronal populations in neurodegenerative diseases was
considered to be the consequence of cell autonomous degeneration of neurons. However …
considered to be the consequence of cell autonomous degeneration of neurons. However …
[HTML][HTML] Theranostic F-SLOH mitigates Alzheimer's disease pathology involving TFEB and ameliorates cognitive functions in Alzheimer's disease models
A Iyaswamy, X Wang, S Krishnamoorthi… - Redox biology, 2022 - Elsevier
Accumulation of amyloid-β (Aβ) oligomers and phosphorylated Tau aggregates are crucial
pathological events or factors that cause progressive neuronal loss, and cognitive …
pathological events or factors that cause progressive neuronal loss, and cognitive …