Both calorie restriction and the ketogenic diet possess broad therapeutic potential in various
clinical settings and in various animal models of neurological disease. Following calorie …

Major brain functions depend on neuronal processes that favor the plasticity of neuronal
circuits while at the same time maintaining their stability. The mechanisms that regulate …

The need for novel, efficacious, antiseizure therapies is widely acknowledged. This study
investigates in humans the feasibility, safety, and efficacy of high‐frequency electrical …

Stable expression of long-term synaptic plasticity is critical for the developmental refinement
of neural circuits and for some forms of learning and memory. Although structural …

The molecular mechanisms of learning and memory, and the underlying bidirectional
changes in synaptic plasticity that sustain them largely implicate protein kinases and …

Fragile X syndrome, the most common form of inherited mental retardation, is caused by
absence of FMRP, an RNA-binding protein implicated in regulation of mRNA translation …

At glutamatergic synapses, the scaffolding protein PSD95 links the neuronal isoform of nitric-
oxide synthase (nNOS) to the N-methyl-d-aspartate (NMDA) receptor. Phosphorylation of …

Persistent activity-induced synaptic modification is generally regarded as the cellular basis
for developmental refinement of neuronal connections and for learning and memory. It has …

Studies of long-term potentiation (LTP) and long-term depression (LTD) strongly suggest
that individual synapses can be bidirectionally modified. A central question is the …

Predisposition of synapses to undergo plastic changes can be dynamically adjusted
according to the history of synaptic activity (ie, synapses are metaplastic). In search of a …