The role of oxidative stress in Parkinson's disease

V Dias, E Junn, MM Mouradian - Journal of Parkinson's …, 2013 - content.iospress.com
Oxidative stress plays an important role in the degeneration of dopaminergic neurons in
Parkinson's disease (PD). Disruptions in the physiologic maintenance of the redox potential …

Glutathione and related molecules in parkinsonism

M Asanuma, I Miyazaki - International journal of molecular sciences, 2021 - mdpi.com
Glutathione (GSH) is the most abundant intrinsic antioxidant in the central nervous system,
and its substrate cysteine readily becomes the oxidized dimeric cystine. Since neurons lack …

Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection

Y Wei, M Lu, M Mei, H Wang, Z Han, M Chen… - Nature …, 2020 - nature.com
Oxidative stress is a major pathogenic mechanism in Parkinson's disease (PD). As an
important cellular antioxidant, glutathione (GSH) balances the production and incorporation …

Attenuation of working memory and spatial acquisition deficits after a delayed and chronic bromocriptine treatment regimen in rats subjected to traumatic brain injury …

AE Kline, JL Massucci, DW Marion… - Journal of …, 2002 - liebertpub.com
Cognitive impairments are pervasive and persistent sequelae of human traumatic brain
injury (TBI). In vivo models of TBI, such as the controlled cortical impact (CCI) and fluid …

Apoptosis-inducing neurotoxicity of dopamine and its metabolites via reactive quinone generation in neuroblastoma cells

ME Haque, M Asanuma, Y Higashi, I Miyazaki… - … et Biophysica Acta (BBA …, 2003 - Elsevier
Neurotoxic properties of l-dopa and dopamine (DA)-related compounds were assessed in
human neuroblastoma SH-SY5Y cells with reference to their structural relationship. l-Dopa …

Pramipexole in psychiatry: a systematic review of the literature.

CB Aiken - Journal of Clinical Psychiatry, 2007 - psychiatrist.com
To estimate short-term rates of intolerable side effects and psychosis, data from all treated
subjects in prospective and retrospective studies of depression (253 subjects from 8 studies) …

Plasma and CSF markers of oxidative stress are increased in Parkinson's disease and influenced by antiparkinsonian medication

C Buhmann, S Arlt, A Kontush, T Möller-Bertram… - Neurobiology of …, 2004 - Elsevier
We determined systemic oxidative stress in Parkinson's disease (PD) patients, patients with
other neurological diseases (OND) and healthy controls by measurement of in vitro …

[PDF][PDF] Short review on dopamine agonists: insight into clinical and research studies relevant to Parkinson's disease

K Radad, G Gille, WD Rausch - Pharmacol Rep, 2005 - if-pan.krakow.pl
Parkinson's disease (PD) is a chronic and progressive neurological disorder characterized
by selective degeneration of dopaminergic neurons (DAergic) in the substantia nigra pars …

[HTML][HTML] Ropinirole hydrochloride remedy for amyotrophic lateral sclerosis–protocol for a randomized, double-blind, placebo-controlled, single-center, and open-label …

S Morimoto, S Takahashi, K Fukushima, H Saya… - Regenerative …, 2019 - Elsevier
Introduction Amyotrophic lateral sclerosis (ALS) is an intractable and incurable neurological
disease. It is a progressive disease characterized by muscle atrophy and weakness caused …

Bromocriptine reduces lipid peroxidation and enhances spatial learning and hippocampal neuron survival in a rodent model of focal brain trauma

AE Kline, JL Massucci, X Ma, RD Zafonte… - Journal of …, 2004 - liebertpub.com
Oxidative stress is a significant contributor to the secondary sequelae of traumatic brain
injury (TBI), and may mediate subsequent neurobehavioral deficits and histopathology. The …