Bone tumors are a rare and heterogeneous group of neoplasms that occur in the bone. The
diversity and considerable morphologic overlap of bone tumors with other mesenchymal …

The last decade has seen the majority of primary bone tumor subtypes become defined by
molecular genetic alteration. Examples include giant cell tumour of bone (H3F3A p. G34W) …

Chordoma is a rare malignant tumor of bone with high morbidity and mortality. Recently,
aggressive pediatric poorly differentiated chordoma with SMARCB1 loss has been …

Revised: 29 March 2016/Accepted: 1 April 2016/Published online: 11 April 2016© Springer-
Verlag Berlin Heidelberg 2016 showing cytological atypia, increased mitotic activity …

Rhabdoid tumors (RT), or malignant rhabdoid tumors, are among the most aggressive and
lethal forms of human cancer. They can arise in any location in the body but are most …

Chordomas are slow-growing malignant neoplasms. Determination of histopathologic
prognostic factors using a large cohort study has been limited by their low incidence. In this …

Chordomas arise in the skull base and spine and usually occur in adults and are rare in the
pediatric population. Cases of chordoma in pediatric age are often poorly differentiated …

Chordoma is a rare malignant bone tumor that can arise anywhere along the central neural
axis and many involve head and neck sites, most commonly the skull base. The relative …

Poorly differentiated chordoma (PDC) is a newly described variant of chordomas, which is
not considered as a subtype yet, but has its own distinct features in terms of morphology …

The fifth edition of the World Health Organization Classification of Tumors of the Central
Nervous System (CNS) now includes mesenchymal tumors that occur uniquely or frequently …