Interactions between antidiabetic drugs and herbs: an overview of mechanisms of action and clinical implications
Diabetes is a complex condition with a variety of causes and pathophysiologies. The current
single target approach has not provided ideal clinical outcomes for the treatment of the …
single target approach has not provided ideal clinical outcomes for the treatment of the …
Role of cytochrome P450 2C8 in drug metabolism and interactions
During the last 10-15 years, cytochrome P450 (CYP) 2C8 has emerged as an important drug-
metabolizing enzyme. CYP2C8 is highly expressed in human liver and is known to …
metabolizing enzyme. CYP2C8 is highly expressed in human liver and is known to …
Pharmacogenomics implications of using herbal medicinal plants on African populations in health transition
The most accessible points of call for most African populations with respect to primary health
care are traditional health systems that include spiritual, religious, and herbal medicine. This …
care are traditional health systems that include spiritual, religious, and herbal medicine. This …
[HTML][HTML] Interactive antimicrobial and toxicity profiles of conventional antimicrobials with Southern African medicinal plants
Z Hübsch, RL Van Zyl, IE Cock… - South African Journal of …, 2014 - Elsevier
Medicinal plant use plays an important role in the healthcare of many South Africans.
Furthermore, in orthodox medicine, conventional antimicrobial agents are amongst the most …
Furthermore, in orthodox medicine, conventional antimicrobial agents are amongst the most …
Cytochrome P450 and P‐Glycoprotein‐mediated interactions involving African herbs indicated for common noncommunicable diseases
Herbal remedies are regularly used to complement conventional therapies in the treatment
of various illnesses in Africa. This may be because they are relatively cheap and easily …
of various illnesses in Africa. This may be because they are relatively cheap and easily …
Herb-drug interactions and their impact on pharmacokinetics: an update
W Cheng, K Xia, S Wu, Y Li - Current Drug Metabolism, 2023 - ingentaconnect.com
Herb medicine has a long history of application and is still used worldwide. With the
development of complementary and alternative medicine, the interaction between herb and …
development of complementary and alternative medicine, the interaction between herb and …
Inhibition of major drug metabolizing CYPs by common herbal medicines used by HIV/AIDS patients in Africa–implications for herb-drug interactions
C Awortwe, PJ Bouic, CM Masimirembwa… - Drug metabolism …, 2013 - ingentaconnect.com
The purpose of this study was to evaluate the potential risk of common herbal medicines
used by HIV-infected patients in Africa for herb-drug interactions (HDI). High throughput …
used by HIV-infected patients in Africa for herb-drug interactions (HDI). High throughput …
In Vitro Reversible and Time-Dependent CYP450 Inhibition Profiles of Medicinal Herbal Plant Extracts Newbouldia laevis and Cassia abbreviata: Implications for …
This study evaluated the effects of Newbouldia laevis and Cassia abbreviata extracts on
CYP450 enzyme activity. Recombinant CYP450 enzyme and fluorogenic substrates were …
CYP450 enzyme activity. Recombinant CYP450 enzyme and fluorogenic substrates were …
The Next Generation Scientist program: capacity-building for future scientific leaders in low-and middle-income countries
Background Scientific and professional development opportunities for early career scientists
in low-and middle-income countries (LMICs) are limited and not consistent. There is a …
in low-and middle-income countries (LMICs) are limited and not consistent. There is a …
Cytochrome P450 enzyme inhibition and herb-drug interaction potential of medicinal plant extracts used for management of diabetes in Nigeria
Abstract Background and Objective The use of herbal medicines is common in Africa, and
patients often use a combination of herbs and drugs. Concurrent herbal and …
patients often use a combination of herbs and drugs. Concurrent herbal and …