Histone modifications are thought to regulate chromatin structure, transcription and other
nuclear processes. Histone methylation was originally believed to be an irreversible …

Myriads of epigenomic features have been comprehensively profiled in health and disease
across cell types, tissues and individuals. Although current epigenomic approaches can …

Trimethylation of histone H3 lysine 4 (H3K4me3) is associated with transcriptional start sites
and has been proposed to regulate transcription initiation,. However, redundant functions of …

Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to
mark the transcription start sites of active genes. Here, we show that H3K4me3 domains that …

It has recently been demonstrated that the genes controlling the epigenetic programmes that
are required for maintaining chromatin structure and cell identity include genes that drive …

Pluripotent stem cells (PSCs) can self-renew or differentiate from naive or more
differentiated, primed, pluripotent states established by specific culture conditions. Increased …

Summary Polycomb repressive complex 1 (PRC1) catalyzes lysine 119 monoubiquitylation
on H2A (H2AK119ub1) and regulates pluripotency in embryonic stem cells (ESCs) …

Severe disease commonly manifests as a systemic inflammatory process. Inflammation is
associated withthe enhanced production of reactive oxygen and nitrogen species and with a …

Compelling evidence suggests that human cognitive function is strongly influenced by
genetics. Here, we conduct a large-scale exome study to examine whether rare protein …

Self-renewal circuitry in embryonic stem cells (ESCs) is increasingly defined. How the robust
pluripotency program is dissolved to enable fate transition is less appreciated. Here we …