Black chokeberry (Aronia melanocarpa) extracts in terms of geroprotector criteria
Abstract Background Black chokeberry (Aronia melanocarpa (Micht.) Elliot) is a great dietary
source of a wide range of biologically active compounds, such as anthocyanins, flavonoids …
source of a wide range of biologically active compounds, such as anthocyanins, flavonoids …
Cytokine-mediated dysregulation of zonula occludens-1 properties in human brain microvascular endothelium
KD Rochfort, PM Cummins - Microvascular research, 2015 - Elsevier
Abstract Zonula occludens-1 (ZO-1) is essential to the proper assembly of interendothelial
junction complexes that control blood–brain barrier (BBB) integrity. The goal of the current …
junction complexes that control blood–brain barrier (BBB) integrity. The goal of the current …
Aronia melanocarpa fruit juice ameliorates the symptoms of inflammatory bowel disease in TNBS-induced colitis in rats
S Valcheva-Kuzmanova, A Kuzmanov… - Food and Chemical …, 2018 - Elsevier
Trinitrobenzensulfonic acid (TNBS) is commonly used to induce an experimental
inflammatory bowel disease (IBD) model. Oxidative stress and inflammation have been …
inflammatory bowel disease (IBD) model. Oxidative stress and inflammation have been …
Occludin oligomeric assemblies at tight junctions of the blood–brain barrier are altered by hypoxia and reoxygenation stress
G McCaffrey, CL Willis, WD Staatz… - Journal of …, 2009 - Wiley Online Library
Hypoxic (low oxygen) and reperfusion (post‐hypoxic reoxygenation) phases of stroke
promote an increase in microvascular permeability at tight junctions (TJs) of the blood–brain …
promote an increase in microvascular permeability at tight junctions (TJs) of the blood–brain …
NADPH oxidase activity in cerebral arterioles is a key mediator of cerebral small vessel disease—implications for prevention
MF McCarty - Healthcare, 2015 - mdpi.com
Cerebral small vessel disease (SVD), a common feature of brain aging, is characterized by
lacunar infarcts, microbleeds, leukoaraiosis, and a leaky blood-brain barrier. Functionally, it …
lacunar infarcts, microbleeds, leukoaraiosis, and a leaky blood-brain barrier. Functionally, it …
Different responsiveness of endothelial cells to vascular endothelial growth factor and basic fibroblast growth factor added to culture media under gravity and …
D Grimm, J Bauer, C Ulbrich, K Westphal… - … Engineering Part A, 2010 - liebertpub.com
When incubated under simulated microgravity (s-μg), endothelial cells (EC) form tubular
structures that resemble vascular intimas. This delayed formation of 3D EC structures begins …
structures that resemble vascular intimas. This delayed formation of 3D EC structures begins …
Occludin oligomeric assembly at tight junctions of the blood‐brain barrier is disrupted by peripheral inflammatory hyperalgesia
G McCaffrey, MJ Seelbach, WD Staatz… - Journal of …, 2008 - Wiley Online Library
Tight junctions (TJs) at the blood‐brain barrier (BBB) dynamically alter paracellular diffusion
of blood‐borne substances from the peripheral circulation to the CNS in response to …
of blood‐borne substances from the peripheral circulation to the CNS in response to …
Hyperglycemic oxoaldehyde, glyoxal, causes barrier dysfunction, cytoskeletal alterations, and inhibition of angiogenesis in vascular endothelial cells: aminoguanidine …
Vascular endothelium is vulnerable to the attack of glucose-derived oxoaldehydes (glyoxal
and methylglyoxal) during diabetes, through the formation of advanced glycation end …
and methylglyoxal) during diabetes, through the formation of advanced glycation end …
Examination of the anti‐inflammatory, antioxidant, and xenobiotic‐inducing potential of broccoli extract and various essential oils during a mild DSS‐induced colitis in …
K Mueller, NM Blum, AS Mueller - … Scholarly Research Notices, 2013 - Wiley Online Library
Phytogenic compounds with antioxidant and anti‐inflammatory properties are currently
discussed as promising complementary agents in prevention and treatment of inflammatory …
discussed as promising complementary agents in prevention and treatment of inflammatory …
Loss of glutathione S‐transferase A4 accelerates obstruction‐induced tubule damage and renal fibrosis
A Liang, Y Wang, LE Woodard… - The Journal of …, 2012 - Wiley Online Library
Glutathione transferase isozyme A4 (GSTA4) exhibits high catalytic efficiency to metabolize
4‐hydroxynonenal (4‐HNE), a highly reactive lipid peroxidation product that has been …
4‐hydroxynonenal (4‐HNE), a highly reactive lipid peroxidation product that has been …