[HTML][HTML] 4-1BB agonists: multi-potent potentiators of tumor immunity

T Bartkowiak, MA Curran - Frontiers in oncology, 2015 - frontiersin.org
Immunotherapy is a rapidly expanding field of oncology aimed at targeting, not the tumor
itself, but the immune system combating the cancerous lesion. Of the many approaches …

Current challenges for cancer vaccine adjuvant development

WS Bowen, AK Svrivastava, L Batra… - Expert review of …, 2018 - Taylor & Francis
Introduction: Although much progress has been made in the last decade (s) toward
development of effective cancer vaccines, there are still important obstacles to therapeutic …

[HTML][HTML] Immunotherapy for human papillomavirus-associated disease and cervical cancer: review of clinical and translational research

SJ Lee, A Yang, TC Wu… - Journal of gynecologic …, 2016 - synapse.koreamed.org
Cervical cancer is the fourth most lethal women's cancer worldwide. Current treatments
against cervical cancer include surgery, radiotherapy, chemotherapy, and anti-angiogenic …

The TNFRs OX40, 4-1BB, and CD40 as targets for cancer immunotherapy

AE Moran, M Kovacsovics-Bankowski… - Current opinion in …, 2013 - Elsevier
T cell-mediated rejection of tumors requires signals from the T cell receptor and co-
stimulatory molecules to license effector functions of tumor-antigen specific T cells. There is …

DNA vaccination for cervical cancer; a novel technology platform of RALA mediated gene delivery via polymeric microneedles

AA Ali, CM McCrudden, J McCaffrey… - … , Biology and Medicine, 2017 - Elsevier
Abstract HPV subtypes (16, 18) are associated with the development of cervical cancer, with
oncoproteins E6 and E7 responsible for pathogenesis. The goal of this study was to …

Immunotherapy and targeted therapy for cervical cancer: an update

G Menderes, J Black, CL Schwab… - Expert review of …, 2016 - Taylor & Francis
The prognosis of patients with metastatic cervical cancer is poor with a median survival of 8–
13 months. Despite the potency of chemotherapeutic drugs, this treatment is rarely curative …

[HTML][HTML] Genital human papillomavirus infections: current and prospective therapies

MA Stanley - Journal of general virology, 2012 - microbiologyresearch.org
Infection with human papillomaviruses (HPVs) is very common and associated with benign
and malignant epithelial proliferations of skin and internal squamous mucosae. A subset of …

Self-adjuvanting polymer–peptide conjugates as therapeutic vaccine candidates against cervical cancer

TY Liu, WM Hussein, Z Jia, ZM Ziora… - …, 2013 - ACS Publications
Dendrimers are structurally well-defined, synthetic polymers with sizes and physicochemical
properties often resembling those of biomacromolecules (eg, proteins). As a result, they are …

Therapeutic vaccination against human papilloma virus induced malignancies

SH Van Der Burg, CJM Melief - Current opinion in immunology, 2011 - Elsevier
Human Papilloma Virus (HPV)-induced (pre-) malignancies offer an excellent case for the
rational design of immunotherapeutic strategies against cancer. Transformed cells express …

[HTML][HTML] Perspectives for preventive and therapeutic HPV vaccines

K Lin, K Doolan, CF Hung, TC Wu - Journal of the Formosan Medical …, 2010 - Elsevier
Human Papillomavirus (HPV) has been associated with several human cancers, including
cervical cancer, vulvar cancer, vaginal and anal cancer, and a subset of head and neck …