Insulin synthesis in pancreatic β‐cells is initiated as preproinsulin. Prevailing glucose
concentrations, which oscillate pre‐and postprandially, exert major dynamic variation in …

Background The discovery of insulin 100 years ago and its ongoing use since that time in
the treatment of diabetes belies the molecular complexity of its structure and that of its …

Insulin plays a central role in the regulation of human metabolism. The hormone is a 51-
residue anabolic protein that is secreted by the β-cells in the Islets of Langerhans …

I present here a personal perspective on more than three decades of research into the
structural biology of the insulin–receptor interaction. The solution of the three‐dimensional …

Throughout much of the last century insulin served a central role in the advancement of
peptide chemistry, pharmacology, cell signaling and structural biology. These discoveries …

Insulin provides a classical model of a globular protein, yet how the hormone changes
conformation to engage its receptor has long been enigmatic. Interest has focused on the C …

Ingestion of vertebrate blood is essential for egg maturation and transmission of disease-
causing parasites by female mosquitoes. Prior studies with the yellow fever mosquito, Aedes …

Progress in solving the structure of insulin bound to its receptor has been slow and stepwise,
but a milestone has now been reached with a refined structure of a complex of insulin with a …

Abstract Background: Lys B28 Pro B29-human insulin (Humalog TM), a fully potent insulin
analog in which the prolyl, lysyl sequence at the C-terminal end of the B-chain is inverted …

The three-dimensional solution structure of the phenol-stabilized 36 kDa R6 insulin hexamer
was determined by NMR spectroscopy and restrained molecular dynamics. The hexamer …