Combining proteins with n-3 PUFAs (EPA+ DHA) and their inflammation pro-resolution mediators for preservation of skeletal muscle mass

R Blaauw, PC Calder, RG Martindale, MM Berger - Critical Care, 2024 - Springer
The optimal feeding strategy for critically ill patients is still debated, but feeding must be
adapted to individual patient needs. Critically ill patients are at risk of muscle catabolism …

Amino acid kinetics in the critically ill

NEP Deutz, KL Haines, PE Wischmeier… - Current Opinion in …, 2024 - journals.lww.com
Novel tracer and computational approaches have been developed to simultaneously
measure postabsorptive kinetics of multiple amino acids that can be used in critical illness …

Tissue-specific reprogramming of glutamine metabolism maintains tolerance to sepsis

BP Leitner, WD Lee, W Zhu, X Zhang, RC Gaspar… - PLoS …, 2023 - journals.plos.org
Reprogramming metabolism is of great therapeutic interest for reducing morbidity and
mortality during sepsis-induced critical illness. Disappointing results from randomized …

[HTML][HTML] Impact of β− hydroxy-β− methylbutyrate (HMB) on muscle loss and protein metabolism in critically ill patients: A RCT

MV Viana, F Becce, O Pantet, S Schmidt, G Bagnoud… - Clinical Nutrition, 2021 - Elsevier
Purpose Muscle wasting deteriorates life quality after critical illness and increases mortality.
Wasting starts upon admission to intensive care unit (ICU). We aimed to determine whether …

ESPEN practical and partially revised guideline: clinical nutrition in the intensive care unit

P Singer, AR Blaser, MM Berger, PC Calder, M Casaer… - Clinical Nutrition, 2023 - Elsevier
Following the new ESPEN Standard Operating Procedures, the previous 2019 guideline to
provide best medical nutritional therapy to critically ill patients has been shortened and …

Females have a different metabolic response to critical illness, measured by comprehensive amino acid flux analysis

NEP Deutz, P Singer, RA Wierzchowska-McNew… - Metabolism, 2023 - Elsevier
Background The trajectory from healthy to critical illness is influenced by numerous factors,
including metabolism, which differs substantially between males and females. Whole body …

Plasma amino acid concentrations in children with severe malaria are associated with mortality and worse long-term kidney and cognitive outcomes

AL Conroy, TM Tran, C Bond, RO Opoka… - The Journal of …, 2022 - academic.oup.com
Background Global changes in amino acid levels have been described in severe malaria
(SM), but the relationship between amino acids and long-term outcomes in SM has not been …

Abdominal obesity in COPD is associated with specific metabolic and functional phenotypes

CL Cruthirds, NEP Deutz, YGG Mizubuti… - Nutrition & …, 2022 - Springer
Background Abdominal obesity (AO) is linked to reduced health status and mortality. While it
is known that AO is prevalent in chronic obstructive pulmonary disease (AO-COPD), the …

Influence of microbial metabolites and itaconic acid involved in bacterial inflammation on the activity of mitochondrial enzymes and the protective role of alkalization

N Fedotcheva, N Beloborodova - International Journal of Molecular …, 2022 - mdpi.com
Human microbiota produces metabolites that may enter the bloodstream and exert systemic
influence on various functions including mitochondrial. Mitochondria are not only a target for …

A low postabsorptive whole body protein balance is associated with markers of poor daily physical functioning in Chronic Obstructive Pulmonary Disease

CL Cruthirds, NEP Deutz, R Harrykissoon, AJ Zachria… - Clinical Nutrition, 2022 - Elsevier
Background & aims Postabsorptive whole body protein kinetics are related to age, gender,
body mass index (BMI), and habitual protein intake level. It is unclear how protein synthesis …