The biaryl structural motif is a predominant feature in many pharmaceutically relevant and
biologically active compounds. As a result, for over a century1 organic chemists have sought …

Until about 1970, palladium had been used mainly to reduce and oxidize organic
compounds, Pd-catalyzed hydrogenation and Wacker oxidation being representative …

During the last decade a number of powerful asymmetric reactions have emerged as a result
of the growing need to develop efficient and practical syntheses of biologically active …

This review provides a detailed discussion of recent advances in the medicinal chemistry of
camptothecin, a potent antitumor antibiotic. Two camptothecin analogues are presently …

A first-principle method has been successfully developed for the prediction of pKa values of
aromatic heterocyclic compounds in DMSO solution with a precision of 1.1 pKa units …

Since the discovery of the Heck reaction, the process has gained widespread acceptance
within the synthetic community both as a practical tool and a research area. The …

The synthesis of a substituted 2-pyridone ring is a topical area of continuing interest due to
the number of biologically active molecules containing this moiety. Over the last decade …

The Diels–Alder reaction that involves a nitrogen atom in the diene or dienophile is termed
the aza-Diels–Alder reaction. As well as the powerful all-carbon Diels–Alder reaction, the …

Abstract Die von Richard F. Heck Ende der sechziger Jahre entdeckte Palladium‐
katalysierte Kupplung von Aryl‐und Alkenylhalogeniden mit Alkenen hat sich nach …

1. Introduction 8649 2. The C-ring construction approach 8651 2.1. Comins's total synthesis
of (þ)-camptothecin and (^)-mappicine 8651 2.2. Glaxo Wellcome's total synthesis of …