Exploring the evidence for epigenetic regulation of environmental influences on child health across generations

CV Breton, R Landon, LG Kahn, MB Enlow… - Communications …, 2021 - nature.com
Environmental exposures, psychosocial stressors and nutrition are all potentially important
influences that may impact health outcomes directly or via interactions with the genome or …

Causes and consequences of oxidative stress in spermatozoa

RJ Aitken, Z Gibb, MA Baker, J Drevet… - Reproduction, Fertility …, 2016 - CSIRO Publishing
Spermatozoa are highly vulnerable to oxidative attack because they lack significant
antioxidant protection due to the limited volume and restricted distribution of cytoplasmic …

Mitochondrial reactive oxygen species (ROS) production alters sperm quality

R Chianese, R Pierantoni - Antioxidants, 2021 - mdpi.com
Besides ATP production, mitochondria are key organelles in several cellular functions, such
as steroid hormone biosynthesis, calcium homoeostasis, intrinsic apoptotic pathway, and the …

Parental advisory: maternal and paternal stress can impact offspring neurodevelopment

JC Chan, BM Nugent, TL Bale - Biological psychiatry, 2018 - Elsevier
Parental stress exposures are implicated in the risk for offspring neurodevelopmental and
neuropsychiatric disorders, prompting critical examination of preconception and prenatal …

Types, causes, detection and repair of DNA fragmentation in animal and human sperm cells

C González-Marín, J Gosálvez, R Roy - International journal of molecular …, 2012 - mdpi.com
Concentration, motility and morphology are parameters commonly used to determine the
fertilization potential of an ejaculate. These parameters give a general view on the quality of …

Epigenetics and the origins of paternal effects

JP Curley, R Mashoodh, FA Champagne - Hormones and behavior, 2011 - Elsevier
Though there are multiple routes through which parents can influence their offspring, recent
studies of environmentally induced epigenetic variation have highlighted the role of non …

Factors enhancing fish sperm quality and emerging tools for sperm analysis

E Cabrita, S Martínez-Páramo, PJ Gavaia, MF Riesco… - Aquaculture, 2014 - Elsevier
With this review we try to give a comprehensive overview of the current methods used in
research to assess sperm quality. In addition, we identify some of the most important factors …

Sperm DNA: organization, protection and vulnerability: from basic science to clinical applications—a position report

CLR Barratt, RJ Aitken, L Björndahl… - Human …, 2010 - academic.oup.com
This article reports the results of the most recent in a series of EHSRE workshops designed
to synthesize the current state of the field in Andrology and provide recommendations for …

In vitro fertilization (IVF) in mammals: epigenetic and developmental alterations. Scientific and bioethical implications for IVF in humans

P Ventura-Juncá, I Irarrázaval, AJ Rolle, JI Gutiérrez… - Biological Research, 2015 - Springer
The advent of in vitro fertilization (IVF) in animals and humans implies an extraordinary
change in the environment where the beginning of a new organism takes place. In mammals …

An atlas of cell types in the mouse epididymis and vas deferens

VD Rinaldi, E Donnard, K Gellatly, M Rasmussen… - elife, 2020 - elifesciences.org
Following testicular spermatogenesis, mammalian sperm continue to mature in a long
epithelial tube known as the epididymis, which plays key roles in remodeling sperm protein …