Deconstructing a syndrome: genomic insights into PCOS causal mechanisms and classification

M Dapas, A Dunaif - Endocrine reviews, 2022 - academic.oup.com
Polycystic ovary syndrome (PCOS) is among the most common disorders in women of
reproductive age, affecting up to 15% worldwide, depending on the diagnostic criteria …

[HTML][HTML] Plasma proteomic profiles reveal proteins and three characteristic patterns associated with osteoporosis: A prospective cohort study

Y Zheng, J Li, Y Li, J Wang, C Suo, Y Jiang, L Jin… - Journal of Advanced …, 2024 - Elsevier
Introduction Exploration of plasma proteins associated with osteoporosis can offer insights
into its pathological development, identify novel biomarkers for screening high-risk …

[HTML][HTML] Whole-Genome Resequencing Reveals Genetic Diversity and Growth Trait-Related Genes in Pinan Cattle

D Bo, Y Feng, Y Bai, J Li, Y Wang, Z You, J Shen, Y Bai - Animals, 2024 - mdpi.com
Simple Summary Whole-genome resequencing technology is widely applicated in the
genetic breeding research of beef cattle. Pinan cattle are a specialized beef cattle …

[HTML][HTML] Heterozygous mutations in SOX2 may cause idiopathic hypogonadotropic hypogonadism via dominant-negative mechanisms

J Cassin, MI Stamou, KW Keefe, KE Sung, CC Bojo… - JCI insight, 2023 - ncbi.nlm.nih.gov
Pathogenic SRY-box transcription factor 2 (SOX2) variants typically cause severe ocular
defects within a SOX2 disorder spectrum that includes hypogonadotropic hypogonadism …

Spike protein of SARS-CoV-2 suppresses gonadotrophin secretion from bovine anterior pituitaries

DA Abdillah, O Kereilwe, RN Ferdousy… - … of Reproduction and …, 2022 - jstage.jst.go.jp
Coronavirus disease (COVID-19), the ongoing global pandemic, is caused by the severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Recent evidence shows that the …

Gene regulatory activity associated with PCOS revealed DENND1A-dependent testosterone production

L Sankaranarayanan, KJ Brewer, GD Johnson… - bioRxiv, 2024 - biorxiv.org
Polycystic ovary syndrome (PCOS) is among the most common disorders affecting up to
15% of the menstruating population globally. It is the leading cause of anovulatory infertility …

Genetics of polycystic ovary syndrome

T Hardy, AP Rogers, RJ Norman - Human Reproductive and Prenatal …, 2023 - Elsevier
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting women
in their reproductive phase of life. The phenotype of PCOS is heterogeneous, manifesting in …