Inflammation‐related mechanisms in chronic kidney disease prediction, progression, and outcome

S Mihai, E Codrici, ID Popescu… - Journal of …, 2018 - Wiley Online Library
Persistent, low‐grade inflammation is now considered a hallmark feature of chronic kidney
disease (CKD), being involved in the development of all‐cause mortality of these patients …

Urinary and serum biomarkers for the diagnosis of acute kidney injury: an in-depth review of the literature

J Vanmassenhove, R Vanholder… - Nephrology Dialysis …, 2013 - academic.oup.com
Background Acute kidney injury (AKI) remains associated with high morbidity and mortality,
despite progress in medical care. Although the RIFLE (Risk, Injury, Failure, Loss, End-Stage …

Biomarkers of acute kidney injury

VS Vaidya, MA Ferguson… - Annu. Rev. Pharmacol …, 2008 - annualreviews.org
Acute kidney injury (AKI) is a common condition with a high risk of death. The standard
metrics used to define and monitor the progression of AKI, such as serum creatinine and …

Urine NGAL predicts severity of acute kidney injury after cardiac surgery: a prospective study

M Bennett, CL Dent, Q Ma, S Dastrala… - Clinical journal of the …, 2008 - journals.lww.com
Background and objectives: The authors have previously shown that urine neutrophil
gelatinase-associated lipocalin (NGAL), measured by a research ELISA, is an early …

Neutrophil gelatinase–associated lipocalin (NGAL) as a marker of kidney damage

D Bolignano, V Donato, G Coppolino, S Campo… - American journal of …, 2008 - Elsevier
Neutrophil gelatinase–associated lipocalin (NGAL) is a protein belonging to the lipocalin
superfamily initially found in activated neutrophils, in accordance with its role as an innate …

[HTML][HTML] Biomarkers for the diagnosis and risk stratification of acute kidney injury: a systematic review

SG Coca, R Yalavarthy, J Concato, CR Parikh - Kidney international, 2008 - Elsevier
The diagnosis of acute kidney injury (AKI) is usually based on changes in serum creatinine,
but such measurements are a poor marker of acute deterioration in kidney function. We …

Neutrophil gelatinase‐associated lipocalin: pathophysiology and clinical applications

E Singer, L Markó, N Paragas, J Barasch… - Acta …, 2013 - Wiley Online Library
Neutrophil gelatinase‐associated lipocalin (NGAL), a 25 kDa protein produced by injured
nephron epithelia, is one of the most promising new markers of renal epithelial injury. In …

Neutrophil Gelatinase-Associated Lipocalin: AÂ Promising Biomarker for Human Acute Kidney Injury

P Devarajan - Biomarkers in medicine, 2010 - Taylor & Francis
Acute kidney injury (AKI) is a common and serious condition, the diagnosis of which
depends on serum creatinine measurements. Unfortunately, creatinine is a delayed and …

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

DB Kell - BMC medical genomics, 2009 - Springer
Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

Neutrophil gelatinase‐associated lipocalin: A troponin‐like biomarker for human acute kidney injury

P Devarajan - Nephrology, 2010 - Wiley Online Library
Acute kidney injury (AKI) is a common and serious condition, the diagnosis of which
currently depends on functional markers such as serum creatinine measurements …