Bioorthogonal chemistry represents a class of high-yielding chemical reactions that proceed
rapidly and selectively in biological environments without side reactions towards …

Bioorthogonal chemistry is a powerful tool to site-specifically activate drugs in living systems.
Bioorthogonal reactions between a pair of biologically reactive groups can rapidly and …

Recently, click chemistry has provided important advances in biomedical research fields.
Particularly, copper-free click chemistry including strain-promoted azide–alkyne …

Cell-based therapy holds great potential to address unmet medical needs and revolutionize
the healthcare industry, as demonstrated by several therapeutics such as CAR-T cell …

Noncovalent interactions between cells and environmental cues have been recognized as
fundamental physiological interactions that regulate cell behavior. However, the effects of …

Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins,
and other molecules, and has been used in many research fields because of its beneficial …

Synthetic multicellular systems hold promise as models for understanding natural
development of biofilms and higher organisms and as tools for engineering complex multi …

The great demand for tissue and organ grafts, compounded by an aging demographic and a
shortage of available donors, has driven the development of bioengineering approaches …

Due to its simplicity, high efficiency, and chemo-selectivity, bioorthogonal chemistry has
shown a great application potential in pre-targeting. Currently, four bioorthogonal pairs as …

Specific recognition sites exist in cells to bring about encapsulation and consequent
enhancements in stability and selectivity. Methods to create nanofunctionalized cells have …