The cognitive effects of radiotherapy for brain metastases

EJ Lehrer, BM Jones, DR Dickstein, S Green… - Frontiers in …, 2022 - frontiersin.org
Brain metastases are the most common intracranial neoplasm and are seen in upwards of
10-30% of patients with cancer. For decades, whole brain radiation therapy (WBRT) was the …

Preoperative stereotactic radiosurgery for glioblastoma

EJ Lehrer, H Ruiz-Garcia, AD Nehlsen, KK Sindhu… - Biology, 2022 - mdpi.com
Simple Summary Stereotactic radiosurgery (SRS) is a multidisciplinary neurosurgical and
radiation technique that allows for the delivery of a highly conformal dose of ionizing …

Concurrent administration of immune checkpoint inhibitors and single fraction stereotactic radiosurgery in patients with non-small cell lung cancer, melanoma, and …

EJ Lehrer, RO Kowalchuk, J Gurewitz… - International Journal of …, 2023 - Elsevier
Purpose Stereotactic radiosurgery (SRS) and immune checkpoint inhibitors (ICI) are highly
effective treatments for brain metastases, particularly when these therapies are administered …

Imaging-based prevalence of oligometastatic disease: a single-center cross-sectional study

SM Christ, K Pohl, UJ Muehlematter, P Heesen… - International Journal of …, 2022 - Elsevier
Purpose Oligometastatic disease refers to a distinct state in patients with cancer
characterized by a low metastatic burden, with diagnosis being informed by a limited …

Preoperative stereotactic radiosurgery as neoadjuvant therapy for resectable brain tumors

D Crompton, D Koffler, F Fekrmandi, EJ Lehrer… - Journal of neuro …, 2023 - Springer
Purpose Stereotactic radiosurgery (SRS) is a method of delivering conformal radiation,
which allows minimal radiation damage to surrounding healthy tissues. Adjuvant radiation …

[HTML][HTML] Epigenetic modifiers in cancer metastasis

D Hu, T Zhao, C Xu, X Pan, Z Zhou, S Wang - Biomolecules, 2024 - pmc.ncbi.nlm.nih.gov
Metastasis is the primary cause of cancer-related death, with the dissemination and
colonization of primary tumor cells at the metastatic site facilitated by various molecules and …

Specific small interfering RNAs (siRNAs) for targeting the metastasis, immune responses, and drug resistance of colorectal cancer cells (CRC)

H Pallathadka, CY Hsu, RO Saleh, SR Jyothi… - International …, 2024 - Elsevier
Colorectal cancer (CRC) involves various genetic alterations, with liver metastasis posing a
significant clinical challenge. Furthermore, CRC cells mostly show an increase in resistance …

Immune checkpoint inhibition and single fraction stereotactic radiosurgery in brain metastases from non-small cell lung cancer: an international multicenter study of …

EJ Lehrer, AA Khosla, A Ozair, J Gurewitz… - Journal of neuro …, 2023 - Springer
Purpose Approximately 80% of brain metastases originate from non-small cell lung cancer
(NSCLC). Immune checkpoint inhibitors (ICI) and stereotactic radiosurgery (SRS) are …

Estimating the risk of brain metastasis for patients newly diagnosed with cancer

JA Miccio, Z Tian, SS Mahase, C Lin, S Choi… - Communications …, 2024 - nature.com
Background Brain metastases (BM) affect clinical management and prognosis but limited
resources exist to estimate BM risk in newly diagnosed cancer patients. Additionally …

Preoperative stereotactic radiosurgery in the management of brain metastases and gliomas

EJ Lehrer, RO Kowalchuk, H Ruiz-Garcia… - Frontiers in …, 2022 - frontiersin.org
Stereotactic radiosurgery (SRS) is the delivery of a high dose ionizing radiation in a highly
conformal manner, which allows for significant sparing of nearby healthy tissues. It is …