The actin cytoskeleton mediates a variety of essential biological functions in all eukaryotic
cells. In addition to providing a structural framework around which cell shape and polarity …

▪ Abstract The 3-phosphorylated inositol lipids fulfill roles as second messengers by
interacting with the lipid binding domains of a variety of cellular proteins. Such interactions …

The mammalian target of rapamycin (mTOR) governs cell growth and proliferation by
mediating the mitogen-and nutrient-dependent signal transduction that regulates messenger …

Cell adhesion is critical for the genesis and maintenance of both three-dimensional structure
and normal function in tissues. The biochemical entities mediating cell adhesion are …

Mammalian sperm must undergo a series of biochemical and physiological modifications,
collectively called capacitation, in the female reproductive tract prior to the acrosome …

Phospholipase D is a ubiquitous class of enzymes that generates phosphatidic acid as an
intracellular signaling species. The phospholipase D superfamily plays a central role in a …

Endothelial cells (ECs) actively regulate the extravasation of blood constituents. On
stimulation by vasoactive agents and thrombin, ECs change their cytoskeletal architecture …

Accumulating evidence suggests that stellate cells are involved in the regulation of the liver
microcirculation and portal hypertension. Activated hepatic stellate cells have the necessary …

Background: Activation of phospholipase D (PLD) is an important but poorly understood
component of receptor-mediated signal transduction responses and regulated secretion. We …

Two widely expressed mammalian phosphatidylcholine (PC)-specific phospholipases D
(PLD), PLD1 and PLD2, have been identified. Recombinantly expressed PLD2 has high …