[HTML][HTML] Recognition of the SARS-CoV-2 receptor binding domain by neutralizing antibodies
Immediately from the outset of the COVID-19 pandemic, researchers from diverse
biomedical and biological disciplines have united to study the novel pandemic virus, SARS …
biomedical and biological disciplines have united to study the novel pandemic virus, SARS …
Advanced technologies for the development of infectious disease vaccines
Vaccines play a critical role in the prevention of life-threatening infectious disease. However,
the development of effective vaccines against many immune-evading pathogens such as …
the development of effective vaccines against many immune-evading pathogens such as …
Structural insights into hepatitis C virus receptor binding and entry
A Kumar, RA Hossain, SA Yost, W Bu, Y Wang… - Nature, 2021 - nature.com
Hepatitis C virus (HCV) infection is a causal agent of chronic liver disease, cirrhosis and
hepatocellular carcinoma in humans, and afflicts more than 70 million people worldwide …
hepatocellular carcinoma in humans, and afflicts more than 70 million people worldwide …
Structure of the hepatitis C virus E1E2 glycoprotein complex
Hepatitis C virus (HCV) infection is a leading cause of chronic liver disease, cirrhosis, and
hepatocellular carcinoma in humans and afflicts more than 58 million people worldwide. The …
hepatocellular carcinoma in humans and afflicts more than 58 million people worldwide. The …
Structure of engineered hepatitis C virus E1E2 ectodomain in complex with neutralizing antibodies
MC Metcalf, BM Janus, R Yin, R Wang… - Nature …, 2023 - nature.com
Hepatitis C virus (HCV) is a major global health burden as the leading causative agent of
chronic liver disease and hepatocellular carcinoma. While the main antigenic target for HCV …
chronic liver disease and hepatocellular carcinoma. While the main antigenic target for HCV …
VH1-69 antiviral broadly neutralizing antibodies: genetics, structures, and relevance to rational vaccine design
Broadly neutralizing antibodies (bnAbs) are potential therapeutic molecules and valuable
tools for studying conserved viral targets for vaccine and drug design. Interestingly, antibody …
tools for studying conserved viral targets for vaccine and drug design. Interestingly, antibody …
Hepatitis C virus vaccine: challenges and prospects
The hepatitis C virus (HCV) causes both acute and chronic infection and continues to be a
global problem despite advances in antiviral therapeutics. Current treatments fail to prevent …
global problem despite advances in antiviral therapeutics. Current treatments fail to prevent …
Hepatitis C virus chronicity and oncogenic potential: Vaccine development progress
Y Haga, S Coates, R Ray - Molecular Aspects of Medicine, 2024 - Elsevier
Hepatitis C virus (HCV) infection is a major health problem worldwide. It can cause liver
cirrhosis and hepatocellular carcinoma (HCC), making it a cause of morbidity from liver …
cirrhosis and hepatocellular carcinoma (HCC), making it a cause of morbidity from liver …
Analysis of antibodies from HCV elite neutralizers identifies genetic determinants of broad neutralization
T Weber, J Potthoff, S Bizu, M Labuhn, L Dold… - Immunity, 2022 - cell.com
The high genetic diversity of hepatitis C virus (HCV) complicates effective vaccine
development. We screened a cohort of 435 HCV-infected individuals and found that 2%–5 …
development. We screened a cohort of 435 HCV-infected individuals and found that 2%–5 …
Regions of hepatitis C virus E2 required for membrane association
Hepatitis C virus (HCV) uses a hybrid entry mechanism. Current structural data suggest that
upon exposure to low pH and Cluster of Differentiation 81 (CD81), the amino terminus of …
upon exposure to low pH and Cluster of Differentiation 81 (CD81), the amino terminus of …