Cytokines are thought to be important mediators in physiologic and pathophysiologic
processes affecting the central nervous system (CNS). To explore this hypothesis …

To determine the fate of anti-DNA antibody-bearing B cells in normal mice, we generated
transgenic mice bearing the heavy (H) and light (L) chain genes of a well-characterized anti …

Nuclear factor κB (NF-κB) is a critical regulator of several genes which are involved in
immune and inflammation responses. NF-κB, consisting of a 50-kDa protein (p50) and a 65 …

Using a Xenopus expression-cloning screen, we have isolated Gremlin, a novel antagonist
of bone morphogenetic protein (BMP) signaling that is expressed in the neural crest …

We have isolated a cDNA from a mouse brain library that encodes a protein whose
predicted amino acid sequence is 42% identical and 64% similar to that of the amyloid beta …

DNA is the accepted target for cisplatin, but recent evidence has shed doubt on DNA
synthesis as the critical process. L1210/0 cells incubated for 2 hours with cisplatin progress …

CYP1B1-null mice, created by targeted gene disruption in embryonic stem cells, were born
at the expected frequency from heterozygous matings with no observable phenotype, thus …

Fanconi's anaemia is a rare autosomal recessive disorder characterized by progressive pan-
cytopaenia and a cellular hypersensitivity to DNA crosslinking agents. Four genetic …

Impaired immune responses occur frequently in cancer patients or in tumor-bearing mice,
but the mechanisms of the tumor-induced immune defects remain poorly understood. In an …

Multiple D1 dopaminergic receptor subtypes have been postulated on the basis of
pharmacological, biochemical, and genetic studies. We describe the isolation and …