Precision public health is an emerging practice to more granularly predict and understand
public health risks and customize treatments for more specific and homogeneous …

Organisms are constantly exposed to microbial pathogens in their environments. When a
pathogen meets its host, a series of intricate intracellular interactions shape the outcome of …

Background & Aims The progression of non-alcoholic steatohepatitis (NASH) to fibrosis and
hepatocellular carcinoma (HCC) is aggravated by auto-aggressive T cells. The gut-liver axis …

Mechanisms by which interferon (IFN)-γ activates genes to promote macrophage activation
are well studied, but little is known about mechanisms and functions of IFN-γ-mediated gene …

Malignant melanoma cell-intrinsic PD-1: PD-L1 interaction thrusts tumorigenesis,
angiogenesis, and radioresistance via mTOR hyperactivation to aggravate circumjacent …

IL-10 is essential to maintain intestinal homeostasis. CD4+ T regulatory type 1 (TR 1) cells
produce large amounts of this cytokine and are therefore currently being examined in …

Rare, monogenetic diseases present unique models to dissect gene functions and
biological pathways, concomitantly enhancing our understanding of the etiology of complex …

Systems approaches for the study of immune signaling pathways have been traditionally
based on purified cells or cultured lines. However, in vivo responses involve the coordinated …

Large meta-analyses of rheumatoid arthritis (RA) susceptibility in European (EUR) and East
Asian (EAS) populations have identified> 100 RA risk loci, but genome-wide studies of RA in …

Long noncoding RNAs (lncRNA) expression profiles change in the ischemic brain after
stroke, but their roles in specific cell types after stroke have not been studied. We tested the …