Objective Asthma is a chronic lung disease comprising multiple endotypes and
characterized by periodic exacerbations. A diverse array of T cells has been found to …

Asthma affects 10% of the worldwide population; about 5% of cases are severe with the
need for target therapies such as biologics. All the biologics approved for asthma hit the T2 …

Abstract Rationale and Objective Plasma extracellular vesicles (EVs) represent a vital
source of molecular information about health and disease states. Due to their heterogenous …

Bronchial asthma is a chronic inflammatory disease of the respiratory tract that varies in
terms of clinical presentations (phenotypes) and distinct underlying pathophysiological …

Severe eosinophilic asthma (SEA) is associated with high peripheral blood and airway
eosinophilia, recurrent disease exacerbations and severe airflow limitation. Eosinophilic …

Obese asthma is a unique asthma phenotype that decreases sensitivity to inhaled
corticosteroids, and currently lacks efficient therapeutic medication. Celastrol, a powerful …

Asthma symptoms are often exacerbated by the common-cold-causing rhinovirus (RV). In
this study, we characterized the temporal behavior of circulating exosomal microRNAs …

Common inflammatory ground links obesity, insulin resistance, and asthma. As recognition
of their interplay, one worsening the natural course of the other, is recognised, questions …

Although obesity-related asthma is associated with worse asthma outcomes, optimal
treatment approaches for this complex phenotype are still largely unavailable. This state-of …

Background The immunological mechanisms behind the clinical association between
asthma and obesity in adolescence are not fully understood. This study aimed to find new …