RIG-I and other RNA sensors in antiviral immunity
Pattern recognition receptors (PRRs) survey intra-and extracellular spaces for pathogen-
associated molecular patterns (PAMPs) within microbial products of infection. Recognition …
associated molecular patterns (PAMPs) within microbial products of infection. Recognition …
Detection of microbial infections through innate immune sensing of nucleic acids
Microbial infections are recognized by the innate immune system through germline-encoded
pattern recognition receptors (PRRs). As most microbial pathogens contain DNA and/or …
pattern recognition receptors (PRRs). As most microbial pathogens contain DNA and/or …
Immune signaling by RIG-I-like receptors
YM Loo, M Gale - Immunity, 2011 - cell.com
The RIG-I-like receptors (RLRs) RIG-I, MDA5, and LGP2 play a major role in pathogen
sensing of RNA virus infection to initiate and modulate antiviral immunity. The RLRs detect …
sensing of RNA virus infection to initiate and modulate antiviral immunity. The RLRs detect …
The immunostimulatory nature of mRNA lipid nanoparticles
Abstract mRNA-Lipid nanoparticles (LNPs) are at the forefront of global medical research.
With the development of mRNA-LNP vaccines to combat the COVID-19 pandemic, the …
With the development of mRNA-LNP vaccines to combat the COVID-19 pandemic, the …
Distinct and orchestrated functions of RNA sensors in innate immunity
Faithful maintenance of immune homeostasis relies on the capacity of the cellular immune
surveillance machinery to recognize" nonself", such as the presence of pathogenic RNA …
surveillance machinery to recognize" nonself", such as the presence of pathogenic RNA …
Pattern recognition and signaling mechanisms of RIG-I and MDA5
Most organisms rely on innate immune receptors to recognize conserved molecular
structures from invading microbes. Two essential innate immune receptors, RIG-I and MDA5 …
structures from invading microbes. Two essential innate immune receptors, RIG-I and MDA5 …
An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4
PG Motshwene, MC Moncrieffe, JG Grossmann… - Journal of Biological …, 2009 - ASBMB
Toll-like receptors (TLRs) mediate responses to pathogen-associated molecules as part of
the vertebrate innate immune response to infection. Receptor dimerization is coupled to …
the vertebrate innate immune response to infection. Receptor dimerization is coupled to …
Master sensors of pathogenic RNA–RIG-I like receptors
M Schlee - Immunobiology, 2013 - Elsevier
Initiating the immune response to invading pathogens, the innate immune system is
constituted of immune receptors (pattern recognition receptors, PRR) that sense microbe …
constituted of immune receptors (pattern recognition receptors, PRR) that sense microbe …
Structural mechanism of RNA recognition by the RIG-I-like receptors
M Yoneyama, T Fujita - Immunity, 2008 - cell.com
Cytoplasmic nonself RNA, such as that generated by invading viruses, is recognized by a
family of sensory molecules termed RIG-I-like Receptors (RLRs). Here, we discuss the …
family of sensory molecules termed RIG-I-like Receptors (RLRs). Here, we discuss the …