The central nervous system (CNS) lacks traditionally defined lymphatic vasculature.
However, CNS tissues and barriers compartmentalize the brain, spinal cord, and adjacent …

Single-cell RNA sequencing (scRNA-seq) is a high-throughput transcriptomic approach with
the power to identify rare cells, discover new cellular subclusters, and describe novel genes …

Dysfunctional lymphatic drainage from the central nervous system (CNS) has been linked to
neuroinflammatory and neurodegenerative disorders, but our understanding of the …

Cerebrospinal fluid (CSF), antigens, and antigen-presenting cells drain from the central
nervous system (CNS) into lymphatic vessels near the cribriform plate and dura, yet the role …

Timely relief of edema and clearance of waste products, as well as promotion of anti-
inflammatory immune responses, reduce ischemic stroke pathology, and attenuate harmful …

Discovery of meningeal lymphatic vessels (LVs) in the dura mater, also known as dural LVs
(dLVs) that depend on vascular endothelial growth factor C expression, has raised interest …

Many types of viruses directly or indirectly target the vascular endothelial growth factor
(VEGF) system, which is a central regulator of vasculogenesis and angiogenesis in …

The brain has traditionally been considered an “immune-privileged” organ lacking a
lymphatic system. However, recent studies have challenged this view by identifying the …

传统观点认为, 大脑是一个免疫豁免的独立器官. 但随着研究不断深入, 脑膜淋巴管的发现颠覆了
这一认知, 它的存在表明大脑与外周免疫之间存在着直接的物理和功能联系 …

The vascular system regulates brain clearance through arterial blood flow and lymphatic
drainage of cerebrospinal fluid (CSF). Idiopathic intracranial hypertension (IIH) …