Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

Age‐related macular degeneration (AMD) is a progressive degenerative disease that is the
leading cause of vision loss in the elderly population. Degeneration/dysregulation of the …

Abstract Background/Objectives To assess the safety and efficacy of avacincaptad pegol
(ACP), a C5 inhibitor, for geographic atrophy (GA) secondary to age-related macular …

Age-related macular degeneration (AMD) is a progressive, degenerative disease of the
human retina which in its most aggressive form is associated with the formation of macular …

The retina, an immune privileged tissue, has specialized immune defense mechanisms
against noxious insults that may exist in diseases such as age-related macular degeneration …

The development of clinical interventions that significantly improve human healthspan
requires robust markers of biological age as well as thoughtful therapeutic targets. To …

Background Macular fibrosis causes irreparable vision loss in neovascular age-related
macular degeneration (nAMD) even with anti-vascular endothelial growth factor (VEGF) …

This review highlights the role of three key immune pathways in the pathophysiology of
major retinal degenerative diseases including diabetic retinopathy, age‐related macular …

A wide range of ocular diseases can present with serous subretinal fluid in the macula and
therefore clinically mimic central serous chorioretinopathy (CSC). In this manuscript, we …

Innate immune cells such as neutrophils, monocyte-macrophages and microglial cells are
pivotal for the health and disease of the retina. For the maintenance of retinal homeostasis …