Neuromuscular junctions (NMJs) are specialized synapses in the peripheral nervous system
that allow the transmission of neuronal impulses to skeletal muscles for their contraction …

Background Astrocytes play a crucial, yet not fully elucidated role in the selective motor
neuron pathology in amyotrophic lateral sclerosis (ALS). Among other responsibilities …

Action potential is transmitted to muscle fibers through specialized synaptic interfaces called
neuromuscular junctions (NMJs). These structures are capped by terminal Schwann cells …

Diabetic neuropathic pain (DNP) is a common and devastating complication in patients with
diabetes. The mechanisms mediating DNP are not completely elucidated, and effective …

Muscle atrophy and functional decline (sarcopenia) are common manifestations of frailty and
are critical contributors to morbidity and mortality in older people. Deciphering the molecular …

Expansion of the hexanucleotide repeat GGGGCC in the C9orf72 gene is the most common
genetic factor in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) …

Proprioception is sensed by muscle spindles for precise locomotion and body posture.
Unlike the neuromuscular junction (NMJ) for muscle contraction which has been well …

During aging and neuromuscular diseases, there is a progressive loss of skeletal muscle
volume and function impacting mobility and quality of life. Muscle loss is often associated …

Skeletal muscle fiber is a large syncytium with multiple and evenly distributed nuclei. Adult
subsynaptic myonuclei beneath the neuromuscular junction (NMJ) express specific genes …

The neuromuscular junction (NMJ) is a synapse between motoneurons and skeletal
muscles to control motor behavior. Acetylcholine receptors (AChRs) are restricted at the …