Colorectal cancer (CRC) is still a leading cause of cancer death worldwide. Less than half of
cases are diagnosed when the cancer is locally advanced. CRC is a heterogenous disease …

The telomere is a special functional complex at the end of linear eukaryotic chromosomes,
consisting of tandem repeat DNA sequences and associated proteins. It is essential for …

In normal human cells, telomeres shorten with successive rounds of cell division, and
immortalization correlates with stabilization of telomere length. These observations suggest …

Patients with inoperable pancreatic cancer have a dismal prognosis with a mean life
expectancy of 3–6 months. New treatment modalities are thus urgently needed. Telomerase …

Abstract Purpose: A phase I/II study was conducted to investigate the safety, tolerability and
clinical response to vaccination with a combination of telomerase peptides GV1001 (hTERT …

DNA methylation is an epigenetic process involved in embryonic development,
differentiation and aging. It is 1 of the mechanisms resulting in gene silencing in …

Ectopic expression of telomerase in telomerase-silent cells is sufficient to overcome
senescence and to extend cellular lifespan. We show here that the catalytic subunit of …

Shortening of the telomeric DNA at chromosome ends is postulated to limit the lifespan of
human cells. In contrast, activation of telomerase, the enzyme that synthesizes telomeric …

Abstract Potten, CS Radiation, the Ideal Cytotoxic Agent for Studying the Cell Biology of
Tissues such as the Small Intestine. Radiat. Res. 161, 123–136 (2004). Epithelial tissues are …

The ideal cancer treatment would specifically target cancer cells yet have minimal or no
adverse effects on normal somatic cells. Telomerase, the ribonucleoprotein reverse …