Retroelements are mobile genetic entities that replicate via reverse transcription of a
template RNA. A key component to the life cycle of these elements is the enzyme reverse …

Fission yeasts are an ancient group of fungal species that diverged from each other from
tens to hundreds of million years ago. Among them is the preeminent model organism …

Integrase (IN) and reverse transcriptase (RT) play a central role in transposition of
retroelements. The mechanism of integration by IN and the steps of the replication process …

Viruses replicate using both their own genetic information and host cell components and
machinery. The different genome types have different replication pathways which contain …

Reverse transcription of the human immunodeficiency virus type 1 is characterized by the
formation of a DNA flap at the center of the viral cDNA in between the central polypurine tract …

Experiments were performed to determine the function of a 28-nucleotide untranslated
sequence lying between the envelope gene and the polypurine tract (PPT) sequence in the …

Priming of plus-strand DNA is a critical step in reverse transcription of retroviruses and
retrotrans-posons. All retroelements use an RNase H-resistant oligoribonucleotide spanning …

Similar to the lentiviruses family of retroviruses, foamy viruses (FVs) contain purine-rich
sequences located in the center of the genome. Their function on viral replication or vector …

Retrovirus plus-strand synthesis is primed by a cleavage remnant of the polypurine tract
(PPT) region of viral RNA. In this study, we tested replication properties for Moloney murine …

To better understand the mechanism by which Ty1 RNase H creates the polypurine tract
(PPT) primer, we have demonstrated the polymerase-dependent hydrolytic activity of Ty1 …