The predominant role of matrix metalloproteinase 8 in extracellular matrix turnover,
modulation of inflammatory responses and other physiological processes is well …

Focal cortical dysplasia (FCD) is a developmental brain disorder characterized by localized
abnormalities of cortical layering and neuronal morphology. It is associated with …

Obliterative bronchiolitis (OB) post-lung transplantation involves IL-17–regulated
autoimmunity to type V collagen and alloimmunity, which could be enhanced by …

Lung transplantation is a therapeutic modality frequently used in end-stage lung disease.
Unfortunately, lung transplant recipients have poor clinical outcomes, often due to the …

Chronic lung allograft dysfunction (CLAD) is the major limitation of long-term survival after
lung transplantation. CLAD manifests as bronchiolitis obliterans syndrome (BOS) or …

Proteases play an important role in health and disease of the lung. In the normal lungs,
proteases maintain their homeostatic functions that regulate processes like its regeneration …

Immune responses to human leucocyte antigen (HLA) and self-antigen collagen V (Col-V)
have been proposed in the pathogenesis of chronic rejection (bronchiolitis obliterans …

Lung transplantation has come of age and is now considered a valid treatment for selected
patients with end‐stage lung disease. In recent years, survival rates have much improved …

Background Long-term outcomes of lung transplantation (LTx) remain hampered by chronic
lung allograft dysfunction (CLAD). Matrix metalloproteinase 9 (MMP-9) is a secretory …

Improved diagnostic methods are needed for bronchiolitis obliterans syndrome (BOS), a
serious complication after allogeneic hematopoietic cell transplantation (HCT) and lung …