The field of stem-cell biology has been catapulted forward by the startling development of
reprogramming technology. The ability to restore pluripotency to somatic cells through the …

Current (high throughput omics-based) data support the model that human (malignant) germ
cell tumors are not initiated by somatic mutations, but, instead through a defined locked …

ABSTRACT X chromosome inactivation (XCI) is a key developmental process taking place
in female mammals to compensate for the imbalance in the dosage of X-chromosomal …

The discovery of X-chromosome inactivation (XCI) celebrated its golden anniversary this
year. Originally offered as an explanation for the establishment of genetic equality between …

Abstract Background A Xist RNA decorated Barr body is the structural hallmark of the
compacted inactive X territory in female mammals. Using super-resolution three …

It has been 8 years since the concept of naïve and primed pluripotent stem cell states was
first proposed. Both are states of pluripotency, but exhibit slightly different properties. The …

Various studies have demonstrated that somatic differentiated cells can be reprogrammed
into other differentiated states or into pluripotency, thus showing that the differentiated …

Emerging evidence is shedding light on a large and complex network of epigenetic
modifications at play in human stem cells. This “epigenetic landscape” governs the fine …

The differentiation and reprogramming of cells are accompanied by drastic changes in the
epigenetic profiles of cells. Waddington's classical model clearly describes how …

Female human induced pluripotent stem cell (hiPSC) lines exhibit variability in X-inactivation
status. The majority of hiPSC lines maintain one transcriptionally active X (Xa) and one …