Topical cyclosporine A therapy for dry eye syndrome

CS De Paiva, SC Pflugfelder, SM Ng… - Cochrane Database of …, 2019 - cochranelibrary.com
Background Topical cyclosporine A (also known as ciclosporin A)(CsA) is an anti‐
inflammatory that has been widely used to treat inflammatory ocular surface diseases. Two …

Ocular pharmacokinetics of a topical ophthalmic nanomicellar solution of cyclosporine (Cequa®) for dry eye disease

A Mandal, V Gote, D Pal, A Ogundele, AK Mitra - Pharmaceutical research, 2019 - Springer
Cequa®, a unique and first-in-class preservative free cyclosporine-A (CsA) nanomicellar
topical formulation was recently approved by US FDA for treatment of dry eye disease or …

Intense pulsed light improves signs and symptoms of dry eye disease due to meibomian gland dysfunction: A randomized controlled study

R Toyos, NR Desai, M Toyos, SJ Dell - PLoS One, 2022 - journals.plos.org
Purpose To compare the safety and efficacy of intense pulsed light (IPL) followed by
meibomian gland expression (MGX), against monotherapy of MGX. Methods Patients with …

Liposomes as vehicles for topical ophthalmic drug delivery and ocular surface protection

JJ López-Cano… - Expert opinion on …, 2021 - Taylor & Francis
Introduction: The development of ophthalmic formulations able to deliver hydrophilic and
hydrophobic drugs to the inner structures of the eye and restore the preocular tear film has …

Topical ocular drug delivery systems: Innovations for an unmet need

Y Yang, A Lockwood - Experimental Eye Research, 2022 - Elsevier
The eye is an isolated and complex organ, with multiple robust anatomical and physiological
barriers on the ocular surface which protect it from noxious insults such as the blink reflex …

A randomized, controlled trial of cyclosporine a cationic emulsion in pediatric vernal keratoconjunctivitis: the VEKTIS study

A Leonardi, S Doan, M Amrane, D Ismail, J Montero… - Ophthalmology, 2019 - Elsevier
Purpose Vernal keratoconjunctivitis (VKC) is a chronic, allergic, and potentially severe
ocular disease affecting children and adolescents that can lead to impaired quality of life …

Dry eye disease: a review of epidemiology in Taiwan, and its clinical treatment and merits

YK Kuo, IC Lin, LN Chien, TY Lin, YT How… - Journal of Clinical …, 2019 - mdpi.com
Dry eye disease (DED) has become common on a global scale in recent years. There is a
wide prevalence of DED in different countries based on various ethnicities and environment …

Management of inflammation in dry eye disease: Recommendations from a European panel of experts

EM Messmer, S Ahmad… - European Journal …, 2023 - journals.sagepub.com
Introduction Early initiation of anti-inflammatory therapies is recommended for dry eye
disease (DED) to break the vicious cycle of pathophysiology. However, there is limited …

Selective pharmacologic therapies for dry eye disease treatment: efficacy, tolerability, and safety data review from preclinical studies and pivotal trials

B Shen Lee, M Toyos, P Karpecki, J Schiffbauer… - Ophthalmology and …, 2022 - Springer
Keratoconjunctivitis sicca, also known as dry eye disease (DED), is a prevalent,
multifactorial disease associated with compromised ocular lubrication, ocular surface …

Long-term safety and efficacy of perfluorohexyloctane ophthalmic solution for the treatment of patients with dry eye disease: the KALAHARI study

EE Protzko, BA Segal, MS Korenfeld, S Krösser… - Cornea, 2024 - journals.lww.com
Purpose: The aim of this study was to assess the long-term safety and efficacy of
perfluorohexyloctane (PFHO) ophthalmic drop (formerly NOV03) for treatment of dry eye …