Breast cancer is the second leading cause of cancer deaths among women. The
development of breast cancer is a multi-step process involving multiple cell types, and its …

Abstract The EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway plays prominent roles in
malignant transformation, prevention of apoptosis, drug resistance and metastasis. The …

INTRODUCTION Advances in DNA sequencing technology have enabled the widespread
analysis of breast tumor genomes, creating a catalog of genetic mutations that may initiate or …

Metabolic rewiring is often considered an adaptive pressure limiting metastasis formation;
however, some nutrients available at distant organs may inherently promote metastatic …

Metastases are the leading cause of mortality in patients with cancer. Metastasis formation
requires cancer cells to adapt their cellular phenotype. However, how metabolism supports …

Despite major therapeutic advances in the management of patients with breast cancer,
central nervous system (CNS) metastases remain an intractable problem, particularly in …

In an inducible oncogenesis model, the miR-200 family is inhibited during CSC formation
but not transformation, and inhibition of miR-200b increases CSC formation. Interestingly …

DOT1L has emerged as an anticancer target for MLL-associated leukaemias; however, its
functional role in solid tumours is largely unknown. Here we identify that DOT1L cooperates …

The discovery that cancer can be governed above and beyond the level of our DNA
presents a new era for designing therapies that reverse the epigenetic state of a tumour cell …

Background Epithelial-mesenchymal transition (EMT) is the key process driving cancer
metastasis. Oncogene/self renewal factor BMI-1 has been shown to induce EMT in cancer …