Malaria has been a major global health problem of humans through history and is a leading
cause of death and disease across many tropical and subtropical countries. Over the last …

Despite recent successful efforts to reduce the global malaria burden, this disease remains a
significant global health problem. Only in 2018, malaria caused 228 million clinical …

Parasites have evolved a wide range of mechanisms that they use to evade or manipulate
the host's immune response and establish infection. The majority of the in vivo studies that …

Immune-driven resistance mechanisms are the prevailing host defense strategy against
infection. By contrast, disease tolerance mechanisms limit disease severity by preventing …

The pathogenesis of infectious diseases depends on the interaction of host and pathogen. In
Plasmodium falciparum malaria, host and parasite processes can be assessed by dual RNA …

Excessive host immune responses contribute to severe malaria with high mortality. Here, we
show that PRL2 in innate immune cells is highly related to experimental malaria disease …

The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family has a key role
in parasite survival, transmission, and virulence. PfEMP1 are exported to the erythrocyte …

Cerebral malaria is a leading cause of global morbidity and mortality. Interventions targeting
the underlying pathophysiology of cerebral malaria may improve outcomes compared to …

Transcriptomics, the analysis of genome-wide RNA expression, is a common approach to
investigate host and pathogen processes in infectious diseases. Technical and bioinformatic …

We studied associations between delayed care seeking, demographic, socioeconomic, and
geographic factors and likelihood of severe malaria in Ugandan children. The study was …