The increasing complexity of randomized clinical trials and the practice of obtaining a wide
variety of measurements from study participants have made the consideration of multiple …

Importance Smokers with chronic obstructive pulmonary disease (COPD) have particular
difficulty quitting. Long-term nicotine replacement therapy (LT-NRT) might offer a strategy for …

For a variety of reasons including poorly designed case report forms (CRFs), incomplete or
invalid CRF data entries, and premature treatment or study discontinuations, missing data is …

Background Traumatic brain injury (TBI) is a major cause of death and disability worldwide.
Progesterone has been shown to improve neurologic outcome in multiple experimental …

Background Osteonecrosis of the jaw (ONJ) has been reported in patients receiving
bisphosphonates for metastatic bone disease. ONJ incidence, risk factors, and outcomes …

Background Bevacizumab and erlotinib target different tumour growth pathways with little
overlap in their toxic-effect profiles. On the basis of promising results from a phase 1/2 trial …

OBJECTIVE To test the safety and efficacy of exenatide once weekly (EQW) compared with
metformin (MET), pioglitazone (PIO), and sitagliptin (SITA) over 26 weeks, in suboptimally …

Bringing together leading statisticians, scientists, and clinicians from the pharmaceutical
industry, academia, and regulatory agencies, this volume explores the rapidly growing area …

Objective: To assess the efficacy and safety of aripiprazole versus placebo as adjunctive
treatment to standard antidepressant therapy (ADT) in patients with major depressive …

Importance Hypertension is a leading cause of cardiovascular disease. The results were
previously reported of a trial of home blood pressure (BP) telemonitoring and pharmacist …