Since its inception in 1985, diffusion weighted magnetic resonance imaging has been
evolving and is becoming instrumental in diagnosis and investigation of tissue functions in …

Diffusion-tensor imaging (DTI) is a noninvasive medical imaging tool used to investigate the
structure of white matter. The signal contrast in DTI is generated by differences in the …

In Alzheimer's diseases (AD), tau pathology is strongly associated with cognitive decline.
Preclinical evidence suggests that tau spreads across connected neurons in an activity …

Tau pathology is the main driver of neuronal dysfunction in 4-repeat tauopathies, including
cortico-basal degeneration and progressive supranuclear palsy. Tau is assumed to spread …

In Alzheimer's disease, tau pathology spreads hierarchically from the inferior temporal lobe
throughout the cortex, ensuing cognitive decline and dementia. Similarly, circumscribed …

Importance For the Alzheimer disease (AD) therapies to effectively attenuate clinical
progression, it may be critical to intervene before the onset of amyloid-associated tau …

Shape analysis has been widely used in digital image processing and computer vision, but
they have not been utilized to compare the structural characteristics of the human …

Here we introduce the concept of the local connectome: the degree of connectivity between
adjacent voxels within a white matter fascicle defined by the density of the diffusing spins …

Advances in molecular and structural and functional neuroimaging are rapidly expanding
the complexity of neurobiological understanding of Parkinson's disease (PD). This review …

There is great interest in the study of brain structural connectivity, as white matter
abnormalities have been implicated in many disease states. Diffusion magnetic resonance …