Role of mitochondrial reverse electron transport in ROS signaling: potential roles in health and disease
Reactive Oxygen Species (ROS) can cause oxidative damage and have been proposed to
be the main cause of aging and age-related diseases including cancer, diabetes and …
be the main cause of aging and age-related diseases including cancer, diabetes and …
Oncogenic pathways and the electron transport chain: a dangeROS liaison
Driver mutations in oncogenic pathways, rewiring of cellular metabolism and altered ROS
homoeostasis are intimately connected hallmarks of cancer. Electrons derived from different …
homoeostasis are intimately connected hallmarks of cancer. Electrons derived from different …
Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation
LK Billingham, JS Stoolman, K Vasan… - Nature …, 2022 - nature.com
The NLRP3 inflammasome is linked to sterile and pathogen-dependent inflammation, and
its dysregulation underlies many chronic diseases. Mitochondria have been implicated as …
its dysregulation underlies many chronic diseases. Mitochondria have been implicated as …
High ATP production fuels cancer drug resistance and metastasis: implications for mitochondrial ATP depletion therapy
Recently, we presented evidence that high mitochondrial ATP production is a new
therapeutic target for cancer treatment. Using ATP as a biomarker, we isolated the …
therapeutic target for cancer treatment. Using ATP as a biomarker, we isolated the …
Mitohormesis, an antiaging paradigm
C Bárcena, P Mayoral, PM Quirós - … review of cell and molecular Biology, 2018 - Elsevier
Mitohormesis is a term used to define a biological response where the induction of a
reduced amount of mitochondrial stress leads to an increment in health and viability within a …
reduced amount of mitochondrial stress leads to an increment in health and viability within a …
Upregulation of mitochondrial ATPase inhibitory factor 1 (ATPIF1) mediates increased glycolysis in mouse hearts
In hypertrophied and failing hearts, fuel metabolism is reprogrammed to increase glucose
metabolism, especially glycolysis. This metabolic shift favors biosynthetic function at the …
metabolism, especially glycolysis. This metabolic shift favors biosynthetic function at the …
IF1 ablation prevents ATP synthase oligomerization, enhances mitochondrial ATP turnover and promotes an adenosine-mediated pro-inflammatory phenotype
S Domínguez-Zorita, I Romero-Carramiñana… - Cell Death & …, 2023 - nature.com
Abstract ATPase Inhibitory Factor 1 (IF1) regulates the activity of mitochondrial ATP
synthase. The expression of IF1 in differentiated human and mouse cells is highly variable …
synthase. The expression of IF1 in differentiated human and mouse cells is highly variable …
IF1 promotes oligomeric assemblies of sluggish ATP synthase and outlines the heterogeneity of the mitochondrial membrane potential
I Romero-Carramiñana, PB Esparza-Moltó… - Communications …, 2023 - nature.com
The coexistence of two pools of ATP synthase in mitochondria has been largely neglected
despite in vitro indications for the existence of reversible active/inactive state transitions in …
despite in vitro indications for the existence of reversible active/inactive state transitions in …
A Review of the Inhibition of the Mitochondrial ATP Synthase by IF1 in vivo: Reprogramming Energy Metabolism and Inducing Mitohormesis
A García-Aguilar, JM Cuezva - Frontiers in physiology, 2018 - frontiersin.org
The ATPase Inhibitory Factor 1 (IF1) is the physiological inhibitor of the mitochondrial ATP
synthase. Herein, we summarize the regulation of the expression and activity of IF1 as a …
synthase. Herein, we summarize the regulation of the expression and activity of IF1 as a …
[HTML][HTML] Cancer cell metabolism: Rewiring the mitochondrial hub
To adapt to tumoral environment conditions or even to escape chemotherapy, cells rapidly
reprogram their metabolism to handle adversities and survive. Given the rapid rise of studies …
reprogram their metabolism to handle adversities and survive. Given the rapid rise of studies …